A Novel Immunomodulator, FTY720, Prevents Spontaneous Dermatitis in NC/Nga Mice(Pharmacology)
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概要
- 論文の詳細を見る
Oral administration of a novel immunomodulator, FTY720 (0.1 mg/kg, once a week), completely prevented the spontaneous development of dermatitis in NC/Nga mice. It also strongly suppressed hyper IgE production in serum, as well as hypertrophy of the epidermis and the degranulation of granulocytes in the skin, all of which were observed in mice in which the dermatitis had become established. These results strongly suggest that FTY720 is a promising candidate for treatment of human atopic dermatitis.
- 公益社団法人日本薬学会の論文
- 2004-09-01
著者
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KOHNO Takeyuki
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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TSUJI Takumi
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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HIRAYAMA Kaori
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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WATABE Kazuhito
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
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KOHNO Tomoko
Research Institute for Production Development
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MATSUMOTO Akiko
Research Institute for Production Development
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FUJITA Tetsuro
Research Institute for Production Development
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Tsuji Takumi
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Fujita Tetsuro
Res. Inst. For Production Dev.
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Hirayama Kaori
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Kohno Takeyuki
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Watabe Kazuhito
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
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Matsumoto Akiko
Research Institute For Production And Development
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Fujita Tetsuro
Research Institute for Production and Development
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