Relapse of Experimental Autoimmune Encephalomyelitis after Discontinuation of FTY720 (Fingolimod) Treatment, but Not after Combination of FTY720 and Pathogenic Autoantigen
スポンサーリンク
概要
- 論文の詳細を見る
FTY720 (Fingolimod) is known to have a significant therapeutic effect on experimental autoimmune encephalomyelitis (EAE). Here, we used an EAE mouse model, which had been established by immunizing C57BL/6J mice with a partial peptide of myelin oligodendrocyte glycoprotein (MOG35—55), to examine the relapse of EAE upon discontinuation of treatment with FTY720 alone or in combination with MOG35—55. Relapse was confirmed to occur in all animals (n=6) within one week after discontinuation of FTY720, with increase in the number of lymphocytes infiltrating the spinal cord and demyelination. However, in the case of combination therapy with FTY720 and MOG35—55, relapse following discontinuation of treatment was completely suppressed. The autoantigenic peptide might serve to suppress the clonal selection of relapse-associated autoantigen-specific T cells.
- 公益社団法人 日本薬学会の論文
著者
-
KOHNO Takeyuki
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
-
TSUJI Takumi
Department of Environmental Health Sciences, Faculty of Pharmaceutical Sciences, Setsunan University
-
FUJITA Tetsuro
Research Institute for Production Development
-
Tsuji Takumi
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
-
Fujita Tetsuro
Res. Inst. For Production Dev.
-
Kohno Takeyuki
Department Of Environmental Health Sciences Faculty Of Pharmaceutical Sciences Setsunan University
-
Yoshida Yuya
Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Setsunan University
-
Fujita Tetsuro
Research Institute for Production and Development
関連論文
- A Novel Immunomodulator, FTY720, Prevents Development of Experimental Autoimmune Myasthenia Gravis in C57BL/6 Mice(Pharmacology)
- Assessment of Mucosal Immune Response in Genitourinary Tract Using Urine
- The Effects of Serine Palmitoyltransferase Inhibitor, ISP-I, on UV-Induced Barrier Disruption in the Stratum Corneum
- Effects of Phosphorylation of Immunomodulatory Agent FTY720 (Fingolimod) on Antiproliferative Activity against Breast and Colon Cancer Cells(Medicinal Chemistry)
- Cicadapeptins from a Fungus Isaria sinclairii Inhibit Acetylcholine-Evoked Secretion of Catecholamines from Bovine Adrenal Chromaffin Cells
- Ion Channel Properties of Disulfide-Linked Dimer Derivatives of Peptaibol, Trichosporin-B-VIa
- STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIBIOTIC PEPTIDES WHICH CAUSE Ca^-DEPENDENT CATECHOLAMINE RELEASE
- ISOLATION AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ANTIBIOTIC PEPTIDES, TRICHOSPORIN-Bs, WHICH CAUSE Ca^-DEPENDENT CATECHOLAMINE RELEASE FROM ADRENAL MEDULLARY CHROMAFFIN CELLS
- A Novel Immunomodulator, FTY720, Prevents Spontaneous Dermatitis in NC/Nga Mice(Pharmacology)
- Relapse of Experimental Autoimmune Encephalomyelitis after Discontinuation of FTY720 (Fingolimod) Treatment, but Not after Combination of FTY720 and Pathogenic Autoantigen