The Effects of Serine Palmitoyltransferase Inhibitor, ISP-I, on UV-Induced Barrier Disruption in the Stratum Corneum
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概要
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We examined the effects of ISP-I (myriocin, thermozymocidin)—a potent inhibitor of serine palmitoyltransferase (SPT) which is involved in the ceramide synthetic pathway—on skin barrier function in post-UVB-irradiated hairless mouse skin. Disruption of the skin barrier function after UVB irradiation as represented by the increase in transepidermal water loss (TEWL) was significantly suppressed with ISP-I treatment. In the ISP-I-treated skin, the peak of cell proliferation was observed 24 h earlier than in vehicle-treated skin. In addition, the number of apoptotic cells in ISP-I-treated skin showed a sharp decrease at 48 and 72 h post-irradiation. The number of stratum corneum cell layers was increased in ISP-I-treated skin at 72 h after UVB irradiation; at this time, TEWL in ISP-I-treated skin was lower than that in the vehicle-treated skin. We suggest ISP-I treatment altered cell proliferation and apoptosis after UVB exposure by modulating ceramide synthesis in epidermal cells, resulting in an increase of stratum corneum layers which lessened the effects of irradiation-induced barrier disruption.
著者
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FUJITA Tetsuro
Research Institute for Production Development
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Matsumoto Katsuo
静岡県立大学 薬
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MATSUMOTO Katsuo
POLA Chemical Industries, Inc.
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Mizukoshi Koji
POLA Chemical Industries, Inc.
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Oshima Hiroshi
POLA Chemical Industries, Inc.
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Hirose Ryouji
Mitsui Sugar Co., Ltd.
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Mizukoshi Koji
Pola Chemical Industries Inc.
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Fujita Tetsuro
Research Institute for Production and Development
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