The Essential Structures of ISP-I that Influence Serine Palmitoyltransferase Inhibition in Chinese Hamster Ovary Cells
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概要
- 論文の詳細を見る
We investigated the structure–activity relationship between various ISP-I (myriocin, thermozymocidin) analogous which has sphingosine-like structure and serine palmitoyltransferase (SPT) in Chinese hamster ovary (CHO) cells utilizing sphingolipid production as a marker. Our data suggest that the double bond and/or ketone group within the alkyl chain as well as the alkyl chain are necessary for ISP-I to inhibit SPT. In addition, a serine structure is necessary for SPT inhibitory activity, which confirms previous findings.
著者
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FUJITA Tetsuro
Research Institute for Production Development
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MATSUMOTO Katsuo
POLA Chemical Industries, Inc.
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Mizukoshi Koji
Pola Chemical Industries Inc.
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Hirose Ryoji
Mitsui Sugar Co., Ltd.
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Fujita Tetsuro
Research Institute for Production and Development
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