Study of the Accelerating Effect of Shikonin and Alkannin on the Proliferation of Granulation Tissue in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The present study was carried out to compare the accelerating effect of shikonin and alkannin and to elucidate the expression of CD antigen and histological changes on the proliferation of granulation tissue in rats. Shikonin and alkannin produced a dose-dependent acceleration of the cotton pellet-induced granuloma formation and this accelerating potency of both compounds on the proliferation of granulation tissue was about the same 5 and 10 d after implantation of the cotton pellet. Also, both compounds increased the ratio of CD11b^+ cells in the granulation tissue 5 and 10 d after implantation of the cotton pellet. Both compounds increased the expression of CD11b^+ cells with granulocytes such as macrophages and histiocytes, and then accelerated the proliferation of fibroblasts and collagen fiber. On the other hand, neither compound increased the ratio of CD3^+ cells in the granulation tissue after 5 and 10 d. These results suggest that shikonin and alkannin accelerate the proliferation of granulation tissue induced by the cotton pellet and this accelerating effect may be attributed to an increase in the expression of CD11b^+ cells, and the acceleration of the proliferation of fibroblasts and collagen fiber in the granulation tissue.
- 社団法人日本薬学会の論文
- 1998-04-15
著者
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尾崎 裕
城西大学薬学部
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KATO YOSHIKO
Department of Bacteriology, Osaka City University Medical School
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Kato Y
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Ikeda Norikazu
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Ikeda Norikazu
クラブコスメチックス
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OZAKI Yukihiro
Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences
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SAKAGUCHI Ikuyo
Department of Research and Development, Club Cosmetics Co., Ltd.,
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TUJIMURA Masae
Department of Research and Development, Club Cosmetics Co., Ltd.,
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IKEDA Norikazu
Department of Research and Development, Club Cosmetics Co., Ltd.,
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NAKAYAMA Miki
Department of Research and Development, Club Cosmetics Co., Ltd.,
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SUZUKI Hideyo
Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences
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SATAKE Motoyoshi
Division of Pharmacognosy and Phytochemistry, National Institute of Health Sciences
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Satake M
Institute Of Environmental Science For Human Life Ochanomizu University
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Nakayama Miki
Department Of Research And Development Club Cosmetics Co. Ltd.
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Tsujimura Masae
Institute Of Cosmetic Scineces Club Cosmetics Co. Ltd.
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Ozaki Y
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Ozaki Y
National Inst. Health Sci. Tokyo Jpn
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Ozaki Yukihiro
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Satake Motoyoshi
Division Of Pharmacognosy Phytochemistry And Narcotics National Institute Of Health Sciences
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Satake Motoyoshi
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Sciences
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Sakaguchi Ikuyo
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Satake Motoyoshi
Division Of Pharmacognosy And Phytochemistry National Institute Of Health Science
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Nakayama Miki
Department Of Materials And Molecular Science Graduate School Of Science And Engineering Ibaraki Uni
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Satake Motoyoshi
Division Of Pharmacognosy And Phyochemistry National Institute Of Health Sciences
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Ozaki Yukihiro
Division of Pharmacognosy and Phytochemistry , National Institute of Health Sciences
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