CARDIOVASCULAR ACTIONS OF OPTICAL ISOMERS OF PROPRANOLOL
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概要
- 論文の詳細を見る
Effects of the optical isomers of propranolol on blood pressure in the rat, and in the spinal rat during adrenaline infusion were studied to investigate the mechanism of the pressor action of propranolol. Both isomers of propranolol produced a sustained pressor action in the rat and in the spinal rat infused with adrenaline. The magnitude of the pressor action produced by the d- and l-propranolol was proportional to their β-adrenoceptor blocking activities in the heart as was reported by several investigators. It is concluded that the pressor action of propranolol is due to the blockade of the β-adrenoceptors mediating vasodilation in the skeletal muscle vascular beds.
- 社団法人 日本薬理学会の論文
著者
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KATO YOSHIKO
Department of Bacteriology, Osaka City University Medical School
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Sekiya Atsushi
Department Of Public Health/health Information Dynamics Field Of Social Life Science Nagoya Universi
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Yamamoto Junnosuke
Department Of Internal Medicine Kakegawa City General Hospital
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Maekawa Hiroshi
Department Of Mechanical Engineering And Intelligent Systems University Of Electro-communications
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Maekawa Hiroshi
Department Of Mechanical And Control Engineering University Of Electro-communications
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Sekiya Atsushi
Department Of Chemistry And Biochemistry School Of Advanced Science And Engineering Waseda University
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MAEKAWA Hiroshi
Department of Pharmacology, Fujita-Gaknen University, School of Medicine
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KATO Yoshiko
Department of Pharmacology, Fujita-Gaknen University, School of Medicine
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YAMAMOTO Junnosuke
Department of Pharmacology, Fujita-Gaknen University, School of Medicine
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