DIFFERENCES IN THE CARDIAC AND PRESSOR RESPONSES TO PROPRANOLOL OF RATS AND GUINEA PIGS
スポンサーリンク
概要
- 論文の詳細を見る
Propranolol produces a sustained rise in blood pressure in the rat, but little change in the guinea pig. In order to elucidate this distinct difference, the following experiments were carried out: (a) The pressor effect of propranolol was studied while the vascular tone was changed by infusion of several vasoactive substances in the guinea pig; (b) The effect of propranolol on the isolated atria of rats and guinea pigs was also compared. Propranolol always produced a pressor action during the infusion of adrenergic β-stimulating agents, but not during vasopressin infusion. In spontaneously beating or electrically driven guinea pig atria, propranolol reduced the contractile force to a greater extent than in rat atria. It is concluded that the difference in action of propranolol on the blood pressure of rat and guinea pig may be explained by the following two reasons: (a) the β-adrenoceptive vasodilator tone in skeletal muscle is stronger in the rat than in the guinea pig; (b) the heart of the rat is less sensitive to propranolol than that of the guinea pig.
- 社団法人 日本薬理学会の論文
著者
-
Sekiya Atsushi
Department Of Public Health/health Information Dynamics Field Of Social Life Science Nagoya Universi
-
Yamamoto Junnosuke
Department Of Internal Medicine Kakegawa City General Hospital
-
Sekiya Atsushi
Department Of Chemistry And Biochemistry School Of Advanced Science And Engineering Waseda University
-
SEKIYA Atsushi
Department of Pharmacology, Fujita-Gakuen University, School of Medicine
-
YAMAMOTO Junnosuke
Department of Pharmacology, Fujita-Gakuen University, School of Medicine
関連論文
- Eating Fast Leads to Obesity : Findings Based on Self-administered Questionnaires among Middle-aged Japanese Men and Women
- Autopsy case of the cerebellar form of progressive multifocal leukoencephalopathy without immunodeficiency
- An autopsy case of the schizophrenic 32 years after lobotomy
- Autopsy case of miliary tuberculosis with cerebral involvement in renal failure
- ROLE OF β-RECEPTOR VASCULAR TONE IN THE VASODILATING ACTION OF SOME DRUGS
- EFFECTS OF SEVERAL β-BLOCKERS ON BLOOD PRESSURE IN THE RAT
- Polysomnographic features of idiopathic central sleep apnea
- CARDIOVASCULAR ACTIONS OF OPTICAL ISOMERS OF PROPRANOLOL
- DIFFERENCES IN THE CARDIAC AND PRESSOR RESPONSES TO PROPRANOLOL OF RATS AND GUINEA PIGS
- EFFECT OF HYPOTHYROID STATUS ON MYOCARDIAL RESPONSES TO SYMPATHOMIMETIC DRUGS
- CARDIOVASCULAR ACTION OF PROPRANOLOL IN RATS UNDER VARIOUS ANESTHETIC PROCEDURES
- STUDIES ON THE VASCULAR ACTION OF BRADYKININ
- Identification of Angiogenic Regulatory Domains of Fibril-Forming Collagens Using Collagen-Like Triple Helical Peptides
- High-Throughput Turbidimetric Screening for Heparin-Neutralizing Agents and Low-Molecular-Weight Heparin Mimetics
- STUDIES ON THE POTASSIUM CONTENT OF THE HEART MUSCLE RECEIVING κ-STROPHANTHIN AND THE INFLUENCE OF POTASSIUM ON THE RESPIRATION OF HEART MUSCLE
- ON THE PHARMACOLOGICAL ACTION OF 16-ACETYL DIGITALINUM VERUM