ROLE OF β-RECEPTOR VASCULAR TONE IN THE VASODILATING ACTION OF SOME DRUGS
スポンサーリンク
概要
- 論文の詳細を見る
In a previous experiment, the pressor action of propranolol was observed in the spinal rat in which the β-receptor vascular tone was induced by infusions of β-adrenergic stimulating agents. This pressor action is considered to be due to the blockade of the β-adrenoceptive vasodilator tone provided by β-stimulants in the peripheral vessel. In this experiment, the pressor action of propranolol was used to investigate the mechanism of the vasodilator action of some vasodilators. Nylidrin, isoxsuprine, bamethan, acetylcholine and papaverine were used as vasodilators. Propranolol produced a pressor action in the spinal rat during infusions of the mixture of nylidrin, isoxsuprine or bamethan and vasopressin, but not during infusions of the mixture of papaverine or acetylcholine and vasopressin. This observation suggests that nylidrin, isoxsuprine and bamethan caused vasodilation through stimulation of β-vascular receptors. This method could be used to ascertian the role of β-receptor activation as a mechanism for the vasodilator action of some drugs.
- 社団法人日本循環器学会の論文
- 1974-02-20
著者
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Maeda Kiyoshi
Dept. Of Intern. Med. Nagoya Univ. Branch Hosp.
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Sekiya Atsushi
Dept. Of Pharmacol. Fujita-gakuen Univ. School Of Med.
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Sekiya Atsushi
Department Of Public Health/health Information Dynamics Field Of Social Life Science Nagoya Universi
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Kobayashi Kaizo
Dept. of Intern. Med., Nagoya Univ. Branch Hosp.
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Kobayashi Kaizo
Dept. Of Intern. Med. Nagoya Univ. Branch Hosp.
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KOBAYASHI Kaizo
Department of Internal Medicine, Nagoya University Branch Hospital
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KATO SHIGENOBU
Department of Internal Medicine, Nagoya University Brach Hospital
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Sekiya Atsushi
Department Of Chemistry And Biochemistry School Of Advanced Science And Engineering Waseda University
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