ON THE PHARMACOLOGICAL ACTION OF 16-ACETYL DIGITALINUM VERUM
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概要
- 論文の詳細を見る
Digitalinum verum is a cardiac glycoside which was discovered at first by Kiliani (1) in digitalis seeds. Its pharmacological action was inves.igated by Fromherz (2), Chen (3) and one of the authors (4). Rec intly Okano <I>et al</I>. (5) produced 16-acetyl digitalinum verum (16AD) by partial acetylation of digitalinum verum (Fig. 1). This glycoside is highly soluble in water though parent compound, digitalinum verum is not. We used various animals to study the pharmacological action of this substance, and found that it was a much more potent and rapid ac ing compound than its parent.
- 公益社団法人 日本薬理学会の論文
著者
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Iida Minoru
Department Of Domestic Science Tokyo Bunka Junior College
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Sekiya Atsushi
Department Of Chemistry And Biochemistry School Of Advanced Science And Engineering Waseda University
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KANDA ZENGO
Department of Pharmacology, Nagoya University School of Medicine
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KANDA ZENGO
Department of Pharnucology, Nagoya University School of Medicine
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KATAYAMA KAZUYUKI
Department of Pharnucology, Nagoya University School of Medicine
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IIDA MINORU
Department of Pharnucology, Nagoya University School of Medicine
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- ON THE PHARMACOLOGICAL ACTION OF 16-ACETYL DIGITALINUM VERUM