STUDIES ON EXPERIMENTAL SHOCK AND ITS PREVENTION IN GUIVEA PIGS BEING APPLIED STIMULATION TO THE PALATE
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概要
- 論文の詳細を見る
(1) Experimental shock was produced in guinea pigs by instituting injection of croton oil into submucous tissue of the palate.(2) In order to produce shock in these animals 0.1 cc of croton oil proved to be sufficient and 35% of the number thus treated resulted in death due to shock; whereas the number of deaths due to administration of similar agent and dosage into abdominal subcutaneous tissue proved to be none whatsoever.(3) From these facts, it is conjectured that the region of the palate might be more vulnerable to causation of shock than areas elsewhere; that the resulting shock of the present experiment might be due to undue stimulation of the autonomic nervous system.(4) Pathologically the most remarkable changes were in the circulatory system and further degenerative changes were added to these changes.(5) Succeeded in preventing the state of shock caused from croton oil injection by using Chlorpromazine as the medicament before and after the croton oil injection. (made all the eighteen (18) animals possible to survive)(6) In order to examine the medicating effect of Chlorpromazine to the state of shock, made the test executing the administration of Chlorpromazine simultaneously with that of croton oil, but it proved to be ineffective.(7) Made clear the Chlorpromazine's restraining action to the state of shock by the histological examination on the visceral organs (lung, liver, kidney, adrenal gland).
- The Keio Journal of Medicineの論文
著者
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Suzuki Yasunobu
Department Of Applied Chemistry Faculty Of Science And Engineering Chuo University
-
Iida Minoru
Department Of Domestic Science Tokyo Bunka Junior College
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SUZUKI YASUNOBU
Department of Oto-rhino-laryngology, School of Medicine, Keio University
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FUKAZAWA HISAO
Department of Oto-rhino-laryngology, School of Medicine, Keio University
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IIDA MINORU
Department of Oto-rhino-laryngology, School of Medicine, Keio University
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