BLEOMYCIN IN MALIGNANT TUMORS OF HEAD AND NECK

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概要

• 論文の詳細を見る

• Bleomycin, discovered and developed by H. Umezawa in 1965, was adminis-tered to 50 patients with malignant tumors in head and neck. The doses and methods of administration were as follows : 10-15 mg-potency/day with intra-arterial infusion method, 10-30 mg-potency/day with intravenous injection and 15 mg-potency/day with local injection method. The effect of the drug was evaluated according to the changes of the tumors through gross observation in most cases. The remarkable effect was observed in 27.3% of intravenous in-jection group (the efficiency rate 59.1%), in 47.4% of intra-arterial infusion group (the efficiency rate 80%) and in 12% of local injection group. Side effects were rash, fever, stomatitis and anorexia, and these were appeared in 54% of the entire cases. No disturbance of the hematopoietic organs was observed.

• The Keio Journal of Medicineの論文

著者

• Suzuki Yasunobu

  Department Of Applied Chemistry Faculty Of Science And Engineering Chuo University

• Fujii Kazuyoshi

  Department Of Otorhinolaryngology School Of Medicine Tokai University

• Miyake Hirosato

  Department Of Otolaryngology School Of Medicine Tokai University

• Inuyama Yukio

  Department Of Otolaryngology And Head And Neck Surgery Hokkaido University Graduate School Of Medici

• Sakai Makoto

  Department Of Biology School Of Education Waseda University

• MATSUKAWA JUNICHI

  Department of Otorhinolaryngology, School of Medicine, Keio University

• FUJII KAZUYOSHI

  Department of Otorhinolaryngology, School of Medicine, Keio University

• INUYAMA YUKIO

  Department of Oto-rhino-laryngology, School of Medicine, Keio University

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