Thyrotropic Activity of Various Adenohypophyseal Hormones of the Bullfrog(Endocrinology)

概要

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The effects of adenohypophyseal hormones of the bullfrog (Rana catesbeiana) origin on the in vitro release of thyroxine (T_4) from the thyroid of prometamorphic larvae were studied. The bullfrog thyrotropin (TSH) preparation was 4 times as potent as bovine TSH in this model. Bullfrog luteinizing hormones (LHS) (I-IV) and follicle-stimulating hormones (FSHS) (I-IV), which were classified according to their isoelectric points, were tested for their thyrotropic activity and demons-trated about 10-40 and 1.5-3% of the activity of bullfrog TSH respectively. Similar activities were also found with LH and FSH preparations separated by immunoaffinity chromatography using monoclonal antibodies against the LH-IV β- and FSH-III β-subunits, respectively. Bullfrog prolactin, growth hormone and adrenocorticotropic hormone did not stimulate T_4 release from the thyroid gland into the medium. The results are discussed with reference to the known indirect (via the adenohypophysis) thyrotropic effects of mammalian thyrotropin-releasing hormone, corticotropin-releasing hormone and luteinizing hormone-releasing hormone.
社団法人日本動物学会の論文
1991-10-15