EFFECT OF HEMATOCRIT AND VISCOSITY ON CORONARY CIRCULATION AND MYOCARDIAL OXYGEN UTILIZATION
スポンサーリンク
概要
- 論文の詳細を見る
The elevation of hematocrit is known to provoke myocardial ischemia in various clinical conditions. In order to clarify the effect of hematocrit and blood viscosity on coronary hemodynamics and oxygen utilization, isovolemic exchanges of blood with plasma or packed red cell were performed in ten open chest anesthetized dogs. Hematocrit was varied in the range of 20 to 60%. Coronary blood flow and cardiac output changed inversely with hematocrit. Coronary vascular resistance and blood viscosity elevated in logarithmic relation to hematocrit. Coronary vascular resistance and blood viscosity revealed linear relationship, the coronary vascular hindrance (resistance/viscosity) remaining constant for the hematocrit range of 20 to 60%. The arterial oxygen content increased linearly with the elevation of hematocrit, and the myocardial oxygen extraction rate was unchanged. The systemic oxygen transport rate increased with hematocrit. However, the left ventricular oxygen transport rate varied little, although the left ventricular oxygen transport at medium hematocrit was slightly higher than at low or high hematocrit. The myocardial oxygen consumption remained constant at each hematocrit, and the efficiency was high at low hematocrit in the face of the elevated cardiac output. The increase in hematocrit elevated the blood viscosity and played a significant role in determining the coronary vascular resistance. This could induce a disturbance in coronary microcirculation especially in pathological conditions.
- 社団法人日本循環器学会の論文
- 1980-07-20
著者
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Sakai Makoto
Department Of Pathology Tokyo Metropolitan Geriatric Hospital
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Iwasaki Tsutomu
Department Of Internal Medicine Tokyo Metropolitan Geriatric Hospital
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Sakai Makoto
Tokyo Metropolitan Geriatric Hospital Division Of Cardiology
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Shinagawa Tatsuo
Tokyo Metropolitan Geriatric Hospital Division Of Cardiology
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MIFUNE Junichiro
Fukui Cardiovascular Center
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MIFUNE Junichiro
Department of Internal Medicine,Fukui Cardiovascular Center
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Mifune Jun-ichiro
Fukui Cardiovascular Center
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KURAMOTO Kizuku
Department of Internal Medicine,Tokyo Metropolitan Geriatric Hospital
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MATSUSHITA Satoru
Department of Internal Medicine,Tokyo Metropolitan Geriatric Hospital
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MURAKAMI Mototaka
Department of Internal Medicine,Tokyo Metropolitan Geriatric Hospital
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MATSUDA Tamotsu
Department of Internal Medicine (III), Kanazawa University School of Medicine
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SHINAGAWA TATSUO
Department of Medicine, Tokyo Metropolitan Geriatric Hospital and Department of Clinical Physiology,
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MOROKI NOBUTO
Department of Medicine, Tokyo Metropolitan Geriatric Hospital and Department of Clinical Physiology,
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Moroki Nobuto
Tokyo Metropolitan Geriatric Hospital
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Kuramoto Kizuku
Tokyo Metropolitan Geriatric Hospital Division Of Cardiology
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Kanamori Kazuki
Fukui Cardiovascular Center
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Kuramoto Kizuku
Department Of Internal Medicine Tokyo Metropolitan Geriatric Hospital
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Matsushita Satoru
Tokyo Metropolitan Geriatric Hospital Division Of Cardiology
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Mifune Junichiro
Department Of Internal Medicine Fukui Cardiovascular Center
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Mifune Jun-ichiro
Department Of Internal Medicine Fukui Cardiovascular Center
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Matsushita S
Tokyo Metropolitan Geriatric Hospital
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Matsuda Tamotsu
Department Of Medicine Tokyo Metropolitan Geriatric Hospital And Department Of Clinical Physiology T
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Murakami Mototaka
Dept. Of Internal Medicine Tokyo Metropolitan Geriatric Hospital
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Sakai Makoto
Department Of Biology School Of Education Waseda University
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Mifune Junichiro
Department Of Medicine Tokyo Metropolitan Geriatric Hospital And Department Of Clinical Physiology T
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Matsuda Tamotsu
Department Of Internal Medicine (iii) Kanazawa University School Of Medicine
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Kuramoto Kizuku
Department Of Cardiololgy Tokyo Metropolitan Tama Geriatric Hospital
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Matsushita Satoru
Department Of Internal Medicine Tokyo Metropolitan Geriatric Hospital
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Matsushita Satoru
Department Of Cardiololgy Tokyo Metropolitan Tama Geriatric Hospital
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MATSUDA Tamotsu
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
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SHINAGAWA Tatsuo
Department of Internal Medicine, Tokyo Metropolitan Geriatric Hospital
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MURAKAMI Mototaka
Department of Internal Medicine (II), School of Medicine, University of Kanazawa
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