Effects of aging on the cardiopulmonary receptor reflex in hypertensive patients.
スポンサーリンク
概要
- 論文の詳細を見る
In order to evaluate the effects of aging on cardiopulmonary receptor function in hypertensive patients, hemodynamic responses after unloading were studied in middle aged and older hypertensive patients.Twenty-one hypertensive patients were divided into 2 groups according to age. The younger group consisted of 9 patients less than 65 years old (mean age: 57.2 years) and the older group contained 12 patients more than 65 years old (77.2 years). Following 10min rest, deactivation of cardiopulmonary receptors was obtained by reducing central venous pressure through the application of graded negative pressures of -10, -20, and -40mmHg to the lower body. Blood pressure, pulse rate, and forearm blood flow were measured at baseline and at each level of negative pressure. Furthermore, plasma norepinephrine and plasma renin activity levels were measured at baseline and at -40mmHg. Forearm blood flow was measured by venous occlusive plethysmography using a Silastic strain gauge applied around the forearm. Forearm peripheral vascular resistance was calculated by dividing the mean arterial pressure by the forearm blood flow.Baseline mean blood pressure, pulse rate, and peripheral vascular resistance were similar in both age groups. Following lower body negative pressure (LBNP), mean blood pressure and pulse rate did not change, suggesting the selective deactivation of cardiopulmonary receptors. The increase in peripheral vascular resistance at LBNP of -40mmHg in the older group (20.0±6.2) was significantly lower than that in the younger group (15.5±8.9, p<0.05). Furthermore, the increase in peripheral vascular resistance after LBNP was inversely related to age (Y=-0.32X+38.8, r=-0.43, p<0.05). Increases in plasma norepinephrine and plasma renin activity in the older group were not different from those in the younger group.It is concluded that the sensitivity of cardiopulmonary baroreceptor function in hypertensive patients deteriorates with increasing age.
- International Heart Journal刊行会の論文
著者
-
Kanemaru Akiko
Departments Of Cardiology Tokyo Metropolitan Geriatric Hospital
-
Kuwajima Iwao
Department Of Cardilogy Tokyo Metropolitan Geriatric Hospital
-
Hoshino Satoshi
Department Of Precision Engineering School Of Engineering University Of Tokyo
-
Sakai Makoto
Department Of Biology School Of Education Waseda University
-
SUZUKI Yasuko
Department of Mechanical System Engineering, Musashi Institute of Technology
-
Kuramoto Kizuku
Department Of Cardiololgy Tokyo Metropolitan Tama Geriatric Hospital
-
Kuwajima Iwao
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital
-
SHIMOZAWA Tatsuo
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital
-
KURAMOTO Kizuku
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital
-
SUZUKI Yasuko
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital
-
KANEMARU Akiko
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital
-
HOSHINO Satoshi
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital
-
SAKAI Makoto
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital
関連論文
- Diaphragmatic Hernia with Ischemic Bowel Obstruction in Pregnancy : Report of a Case
- PJ-489 Intraventricular Septal Intramural Asynchrony in Patients with Dilated Cardiomyopathy Using Tissue Velocity Imaging Correlates with the Severity of Myocardial Fibrosis(PJ082,Echo/Doppler (Myocardium) (I),Poster Session (Japanese),The 73rd Annual Sc
- PE-259 Patients with Constrictive Pericarditis Have Lower Blood Brain Natriuretic Peptide Levels Because They Have Lower Left Ventricular Transmural Filling Pressures(Neurohumoral Factors 2 (H) : PE44)(Poster Session (English))
- PE-255 Blood BMP Levels as a Prognostic Indicator in Patients with Moderate Pericardial Effusion(Neurohumoral Factors 2 (H) : PE44)(Poster Session (English))
- Quantitative analysis of cisplatin sensitivity of human esophageal squamous cancer cell lines using in-air micro-PIXE
- -126-HYPERKINETIC HEART SYNDROME IN THE AGED HYPERTENSIVES : Hypertension,Catecholamine : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- DECREASE IN c-AMP INDUCED CONTRACTION OF SHR ENDOTHELIAL CELL : Arteriosclerosis : 53 Annual Scientific Meeting, Japanese Circulation Society
- CGRP (HUMAN AND ANALOGUE)-INHIBITION OF HUMAN PLATELET AGGREGATION : Myocardial Metabolism, Biochemistry : 53 Annual Scientific Meeting, Japanese Circulation Society
- Thyrotropic Activity of Various Adenohypophyseal Hormones of the Bullfrog(Endocrinology)
- EFFECT OF HEMATOCRIT AND VISCOSITY ON CORONARY CIRCULATION AND MYOCARDIAL OXYGEN UTILIZATION
- -219-TREATMENT OF ACUTE LEFT-SIDED HEART FAILURE WITH INTRAMUSCULAR INJECTION OF CHLORPROMAZINE : Cardiac FAILURE : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -19-DISTRIBUTION OF ISOZYMES OF ADENOSINE 3':5' MONOPHOSPHATE (cAMP) DEPENDENT PROTEIN KINASE (PK) IN VARIOUS CARDIAC MUSCLES : Cardiac Metabolism : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Calciphylaxis in a Patient with End-Stage Renal Disease Secondary to Systemic Lupus Erythematosus Associated with Acral Gangrene and Mesenteric Ischemia
- PJ-620 High Blood Brain Natriuretic Peptide Levels Are Associated with High Nocturnal Blood Pressures in the Elderly with Hypertension(Cardiac Hypertrophy, Basic and Clinical 2 (M) : PJ104)(Poster Session (Japanese))
- Comparison of cilostazol and ticlopidine for prevention of restenosis and thrombosis after coronary stent implantation
- Characteristics of Body Surface Mapping in the Aged : CLINICAL APPLICATION OF BODY SURFACE MAPPING
- CLINICAL AND EXPERIMENTAL STUDY ON HEMODYNAMIC EFFECTS OF PHLEBOTOMY IN ACUTE PULMONARY EDEMA : Cardiac Performance : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- PATHOGENESIS OF ACUTE REVERESIBLE MYOCARDIAL INFARCTION IN 37 AUTOPSIED CASES : Ischemic Heart disease : Ist Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- COMPARISON OF HEMODYNAMIC EFFECTS OF EXERCISE AND ISOPROTERENOL INFUSION IN NOMAL YOUNG AND OLD MAN
- -35-CORRELATION BETWEEN ANATOMIC MYOCARDIAL INFARCT SIZE, TOTAL CPK RELEASE AND A QRS SCORING SYSTEM IN 12-LEADS ECG
- Blood Pressure Biofeedback Treatment : Clinic Application to White-coat Hypertension.
- COMPARISON OF THE EFFECT OF NIFEDIPINE AND DILTIAZEM ON SERUM DIGOXIN CONCENTRATION. A CROSSOVER STUDY : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Cardiovascular Drugs (I)
- HEMODYNAMIC EFFECTS OF SALBUTAMOL, AN ORAL LONG-ACTING β-STIMULANT, IN PATIENTS WITH CONGESTIVE HEART FAILURE : Ventricular function (I) : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- ELECTROCARDIOGRAPHIC AND HEMODYNAMIC EVALUATIONS OF ISOPROTERENOL TEST IN ELDERLY ISCHEMIC HEART DISEASE
- 3 Does a Beyond Blood Pressure Lowering Effect of Antihypertensive Drug Really Exist?(Practice of Hypertension management, Looking into one's heart,Roundtable Discussion 3 (RT3) (H),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio
- EBM and Commercialis(How to Make Japanese Original Evidence in Cardiology, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- The Effects of Short-Term Blood Pressure Variability and Nighttime Blood Pressure Levels on Cognitive Function
- The Pathogenetic Role and Treatment of Elderly Hypertension : Pathophysiology of Hypertension and its Relation to the Choice of Antihypertensive Treatment
- Improved design methodology for an existing automated transportation system with automated guided vehicles in a seaport container terminal
- Visual-Vestibular Interaction : An evoked potential study in normal human subjects
- Survival Benefit of Screening for Early Esophageal Carcinoma in Head and Neck Cancer Patients
- Effects of Thyrotropin-Releasing Hormone Analogues and Metabolites on Prolactin Release from the Bullfrog Hypophysis(Endocrinology)
- Endoscopic Screening for Esophageal Cancer in 788 Patients with Head and Neck Cancers
- Cardiovascular Disease in the Aged : Overview of an Autopsy Series : PANEL DISCUSSION ON PROBLEMS IN THE TREATMENT OF CARDIOVASCULAR DISEASES IN THE ELDERLY : 51th Annual Scientific Session of the Japanese Circulation Society
- -401- CORONARY ARTERY SCLEROSIS AND MAJOR CAUSES OF DEATH IN OLD PEOPLE
- THE TREATMENT OF MILD HYPERTENSION IN THE ELDERLY, A PROSPECTIVE STUDY USING MULTIPLE REGRESSION ANALYSIS
- Prospective Study on the Treatment of Mild Hypertension in the Aged
- Assessment of Postoperative Hearing in 528 Middle Ear and Mastoid Surgery Cases in Tokai University Hospital
- A New Therapeutic Strategy for Streptococcal Toxic Shock Syndrome : A Key Target for Cytokines
- Heat loss to the combustion chamber wall with deposit in D. I. diesel engine : variation of instantaneous heat flux on piston surface with deposit
- Development of thin film thermocouple for measurement of instantaneous heat flux flowing into the cast iron combustion chamber wall
- The beneficial effect of effective control of anemia on hyperinsulinemia and hypoxemia in a hemodialysis patient with corrected transposition of the great arteries
- NONBACTERIAL THROMBOTIC ENDOCARDITIS AS A CAUSE OF CEREBRAL AND MYOCARDIAL INFARCTION
- The End Results of Treatment of Maxillary Cancer Analysed According to Modality of Preoperative Treatments
- Results and Prognostic Factors in the Radical Sinus Operation for Chronic Sinusitis.
- Deep venous thrombosis, myocardial infarction, and occlusion of vascular access associated with heparin-induced thrombocytopenia in a diabetic hemodialysis patient
- Treatment of Acute Left-Sided Heart Failure with Intramuscular Injection of Chlorpromazine
- Acute Reversible Myocardial Infarction after Blood Transfusion in the Aged
- Studies on the Migratory Properties of Epithelial Cells of Cholesteatoma : Clinical Investigation
- A Clinical study of the Nasal Dilator Nozovent^ in Japanese Subjects
- Canal-Down Tympanoplasty; One-Stage Tympanoplasty with Mastoid Obliteration, for Non-cholesteatomatous Chronic Otitis Media Associated with Osteitis
- Two classes of Lorentzian stationary surfaces in semi-Riemannian space forms
- Surface Roughness and Marginal Fit of Gold Crowns and Gold-Silver-Palladium Crowns Made with Accelerated-type Gypsum-bonded Investments
- THE MATHEMATICAL WORK OF YUSAKU KOMATU
- Spacelike minimal surfaces in 4-dimensional Lorentzian space forms
- EFFECTS OF HYPERTENSION AND ANTIHYPERTENSIVE DRUGS ON CARDIOVASCULAR COMPLICATIONS IN THE ELDERLY
- A Statistical Study of Fistula Auris Congenita in Japan
- Isolated right ventricular infarction resulting from thrombotic occlusion of a hypoplastic right coronary artery.
- A clinicopathological study on valvular diseases in 1,000 consecutive autopsy of the aged.
- Low Salt Intake and Changes in Serum Sodium Levels in the Combination Therapy of Low-Dose Hydrochlorothiazide and Angiotensin II Receptor Blocker
- Effects of aging on the cardiopulmonary receptor reflex in hypertensive patients.
- BLEOMYCIN IN MALIGNANT TUMORS OF HEAD AND NECK
- STUDY ON SHOCK RESULTING FROM STIMULATION OF THE PALATINE AREA BY COCAINE AND ITS PROPHYLAXIS IN GUINEA PIGS
- A Clinicopathological Study on the Electrical Axis of the Heart in 1, 000 Autopsy Cases
- The efficacy and safety of long-term antihypertensive therapy with nifedipine.
- Marked discrepancy in pressure gradient between Doppler and catheter examinations on Medtronic Mosaic valve in aortic position