EFFECTS OF HYPERTENSION AND ANTIHYPERTENSIVE DRUGS ON CARDIOVASCULAR COMPLICATIONS IN THE ELDERLY
スポンサーリンク
概要
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The role of hypertension and antihypertensive drugs in cardiovascular complications was evaluated in 380 elderly people living in the Tokyo Metropolitan Gerontology Center. The subjects were classified into four groups according to the presence or absence of hypertension and their antihypertensive treatment, and followed up prospectively for 5 years from 1979 to 1984. The average age of each group was 74 to 76 years. Cerebrovascular disease was observed in 19.3% of male hypertensive and 10.1% of male normotensives (p=0.078). The drug treated group revealed no cerebral hemorrhage and less cerebral infarction. This tendency was not observed in females. Ischemic heart disease was prevalent in the drug treated group (10.9% vs 4.5%, p=0.023) irrespective of blood pressure level. Risk factors such as body mass index, skinfold thickness, serum cholesterol, albumin, creatinine, blood urea nitrogen and uric acid at entry were elevated in the drug treated group. Diuretics were used in 92% of the drug treated group; in 53% as monotherapy and in 39% as combination therapy with other antihypertensive agents. The metabolic effect of diuretics may increase the incidence of ischemic heart disease in the elderly. We might conclude that hypertension in the aged accelerates cerebrovascular complications, and that antihypertensive treatment is effective even in this group. However, the wide use of diuretics could increase the incidence of ischemic heart disease. Careful selection of antihypertensive drugs as well as dose adjustment are needed in the treatment of elderly hypertensive.
- 社団法人日本循環器学会の論文
- 1988-01-20
著者
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Shibata Hiroshi
Department of Applied Physics, The National Defense Academy
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Kuramoto Kizuku
Department Of Medicine Tokyo Metropolitan Geriatric Hospital
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Kuramoto Kizuku
Department Of Cardiololgy Tokyo Metropolitan Tama Geriatric Hospital
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Shibata Hiroshi
Department Of Epidemiology. Tokyo Metro-politan Institute Of Gerontology
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Matsushita Satoru
Department Of Internal Medicine Tokyo Metropolitan Geriatric Hospital
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Matsushita Satoru
Department Of Medicine Tokyo Metropolitan Geriatric Hospital
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Matsushita Satoru
Department Of Cardiololgy Tokyo Metropolitan Tama Geriatric Hospital
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KURAMOTO Kizuku
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital
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MATSUSHITA Satoru
Department of Cardiology, Tokyo Metropolitan Geriatric Hospital
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