EFFECT OF α-NAPHTHYLISOTHIOCYANATE ON BLOOD CLEARANCE OF ^<99m>Tc-PHYTATE IN RATS

概要

論文の詳細を見る
The effect of α-naphthylisothiocyanate (ANIT) on blood clearance of ^<99m>Tc-phytate (^<99m>Tc-P) in rats was examined, and blood clearance test of ^<99m>Tc-P was compared with the cases of serum transaminase test, serum bilirubin test or histological test of the liver. The disappearance rate of ^<99m>Tc-P from blood decreased with the increase in dose of ANIT and with the passage of time after the ANIT administration. Changes of the blood clearance of ^<99m>Tc-P after ANIT treatment in rats may be influenced by the disorder in the hepatocytes rather than in the bile ductule cells. The blood clearance test of ^<99m>Tc-P in rats showed a sensitive reaction for the acute hepatic dysfunction induced by ANIT equally to the serum transaminase test, the serum bilirubin test or the histological test of the liver.
日本トキシコロジー学会の論文
1989-02-25