BLOOD CLEARANCE OF ^<99m>Tc-PHYTATE FOR EVALUATION OF HEPATIC DYSFUNCTION IN DOGS
スポンサーリンク
概要
- 論文の詳細を見る
Organ distribution pattern, and blood clearance were examined by giving ^<99m>Tc-phytate (^<99m>Tc-P) to the normal dogs. At the same time, the relation between the severity of hepatic function and blood clearance of ^<99m>Tc-P was studied by using the dogs with acute hepatic dysfunction experimentally induced by carbon tetrachloride (CCl_4) administration. Furthermore, a comparative discussion on blood clearance test of ^<99m>Tc-p was made with serum transaminase test. It appeared appropriate to administer ^<99m>Tc-P at the dose of 100 μg/kg in order to obtain an effective blood clearance curve. A major part of <<99m<Tc-p intravenously administered was taken up into the liver, while the remainder of small amount into the spleen, kidneys, lung, and so on. Little was recognized in the thyroid. The disappearance rate of ^<99m>Tc-P from blood decreased with the increase in dose of CCl_4 and with the passage of time after the CCl_4 administration. The blood clearance test of ^<99m>Tc-P in dogs showed a sensitive reaction for the acute hepatic dysfunction induced by CCl_4 equally to the serum transaminase test.
- 日本トキシコロジー学会の論文
- 1988-08-31
著者
-
Kikuya Masahiro
New Industry Creation Hatchery Center Tohoku University
-
Shibata Hiroshi
Department of Applied Physics, The National Defense Academy
-
Kohno M
Yamaguchi Univ. Yamaguchi‐shi Jpn
-
KOHNO Masahiro
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University
-
HISANO Tomoyuki
Department of Veterinary Pharmacology, Faculty of Agriculture, Yamaguchi University
-
Hisano T
Yamahuchi Univ. Yamaguchi Jpn
-
Hisano Tomoyuki
Department Of Veterinary Pharmacology Faculty Of Agriculture Yamaguchi University
-
Kohno Masahiro
Department Of Electronics Faculty Of Engineering Tottori University
-
Kohno Masahiro
Department Of Bioengineering Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Technology
関連論文
- Accumulation of common polymorphisms is associated with development of hypertension : a 12-year follow-up from the Ohasama study
- Impaired Insulin Secretion in Four Tangier Disease Patients with ABCA1 Mutations
- Uncontrolled hypertension based on morning and evening home blood pressure measurements from the J-HOME study
- The association between masked hypertension and waist circumference as an obesity-related anthropometric index for metabolic syndrome : the Ohasama study
- PE-152 Adiponectin Deficiency Suppresses ABCA1 Expression and ApoA-I Synthesis in the Liver(Atherosclerosis, basic(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Evaluation of a Homogeneous Assay for Measuring LDL-cholesterol in Hyperlipidemic Serum Specimens
- PE-151 Adiponectin Promotes Cholesterol Efflux from Human Macrophages throuth ABCA1-dependent Pathway(Atherosclerosis, basic(04)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Proposal of a Risk-Stratification System for the Japanese Population Based on Blood Pressure Levels : The Ohasama Study
- Reproducibility of Nocturnal Blood Pressure Assessed by Self-Measurement of Blood Pressure at Home
- Epidemiology of Hypertension Based on Ambulatory Blood Pressure Monitoring and Self-Measurement of Blood Pressure at Home
- Blood Pressure Control Assessed by Home, Ambulatory and Conventional Blood Pressure Measurements in the Japanese General Population : the Ohasama Study
- Risk Factors and Predictors of Coronary Arterial Lesions in Japanese Hypertensive Patients
- Comparison of Arterial Functional Evaluations as a Predictor of Cardiovascular Events in Hypertensive Patients : The Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) Study
- Electrocardiographic abnormalities and home blood pressure in treated elderly hypertensive patients : Japan home versus office blood pressure measurement evaluation in the elderly (J-HOME-Elderly) study
- PE-159 Familial Intrahepatic Cholestasis 1 (FIC1) Gene Product, a Novel Contributor for Cholesterol Efflux(Atherosclerosis, basic-4 (H) PE27,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- High blood pressure worsens age-related increases in arterial stiffness evaluated by pulse wave velocity in subjects with lifestyle-related diseases
- Intercellular Adhesion Molecule-1 G241R Polymorphism Influences Increasing Arterial Stiffness
- Clinical Significance of High-Molecular Weight Form of Adiponectin in Male Patients With Coronary Artery Disease
- ACE2 Mutant Mice Increase Cardiac Angiotensin II and Increase Incidence of Heart Failure in Response to Pressure Overload (Heart Failure, Basic 7 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Impaired efflux of cholesterol from aged cells and its molecular mechanism : A basis for age-related enhancement of atherosclerosis
- PJ-679 Clinical Significance of High Molecular Weight Form of Adiponectin in Male Patients with Coronary Artery Disease(Diabetes / Obesity / Metabolic syndrome(14)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
- Plasma Adiponectin Concentration and Renal Function, and its Predictive Role in Cardiovascular Disease (Kidney/Renal Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Practice and awareness of physicians regarding home blood pressure measurement in Japan
- Masked Hypertension Determined by Self-Measured Blood Pressure at Home and Chronic Kidney Disease in the Japanese General Population : The Ohasama Study
- Fruit and Vegetable Consumption and the Risk of Hypertension Determined by Self Measurement of Blood Pressure at Home : The Ohasama Study
- Difference between Home and Office Blood Pressures among Treated Hypertensive Patients from the Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) Study
- Factors Affecting Heart Rate as Measured at Home among Treated Hypertensive Patients : The Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) Study
- Current Usage of Diuretics among Hypertensive Patients in Japan : The Japan Home versus Office Blood Pressure Measurement Evaluation (J-HOME) Study
- OE-060 Apo B-48 Is a Good Marker for Coronary Risk and Impaired Metabolism of Chylomicron Remnants in Subjects with Metabolic Syndrome(Lipid disorders-1 (H) OE10,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- Relationships among Blood Pressures Obtained Using Different Measurement Methods in the General Population of Ohasama, Japan
- Determinants of Circadian Blood Pressure Variation : A Community-Based Study in Ohasama
- OE-208 Chylomicron Remnants are Increased in CD36 Deficiency at Postprandial State(Lipid disorders(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-253 Increased Lipid Rafts and Accelerated Lipopolysaccharide-induced Tumor Necrosis Factor α Secretion in Abca1-deficient Macrophages(Lipid disorders-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-043 Defective Cholesterol Efflux Increased Lipid Rafts and Enhanced Lipopolysaccharide-induced Cytokine Release(Atherosclerosis, basic-3 (H) PE8,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society
- OE-079 HDL-mediated Plaque Stabilization through Enhancement of Cholesterol Efflux and Inhibition of a Novel Proinflammatory Cytokine Proepithelin(Atherosclerosis, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-071 Accumulation and Expression of Adiponectin in Damaged Cardiac Tissue Following Ischemia-reperfusion(Myocardial ischemia/reperfusion, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- The Impact of Late Systolic Pressure Augmentation on Left Ventricular Hypertrophy in Untreated Hypertensive Patients(Hypertension, Clinical 6 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Practical Aspect of Monitoring Hypertension Based on Self-measured Blood Pressure at Home
- CYP11B2 Polymorphisms and Home Blood Pressure in a Population-Based Cohort in Japanese : the Ohasama Study
- A/C^ Gene Polymorphism of the Angiotensin II Type 1 Receptor (AT1) and Ambulatory Blood Pressure : the Ohasama Study
- T+31C Polymorphism (M235T) of the Angiotensinogen Gene and Home Blood Pressure in the Japanese General Population : the Ohasama Study
- Genetic polymorphisms in the beta-subunit of the epithelial sodium channel (βENaC) gene in the Japanese population
- Relationship of dysregulation of glucose metabolism with white-coat hypertension : the Ohasama study
- Practice and awareness of physicians regarding casual-clinic blood pressure measurement in Japan
- Lower Lamb Wave Resonance Mode of Thin Cylindrical Shells
- Effect of Thin Cylindrical Shell Vibration on Resonant Frequency of Cylindrical Resonator-Type Sound Source
- Carbonated soft drinks and carbonyl stress burden
- PE-254 Pitavastatin Improved Postprandial Hypertriglyceridemia Caused by the Accelerated Intestinal Lipid Absorption in Cd36 Deficiency(Lipid disorders-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Novel ELISA for Apo B-48 Revealed the Accumulation of Chylomicron Remnants in Diabetic Patients, Predisposing Them to Coronary Heart Disease (Diabetes/Obesity 7 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-115 Atherogenic Profiles of CD36-deficient Macrophages(Clinical Aspects of Atherosclerosis (H) FRS23,Featured Research Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 4 Adiponectin Accelerates Reverse Cholesterol Transport by Increasing HDL Assembly in the Liver and by Enhancing Cholesterol Efflux from Foam Cells(Hypoalphalipoproteinemia, Its Pathogenesis and Treatments, The 71st Annual Scientific Meeting of the Japane
- Effects of External Noise on Anomalous Diffusion in Hamiltonian Dynamical Systems
- Simultaneous Resection of Gastric Carcinoma and Splenectomy in a Patient with Polycythemia Vera : Report of a Case
- BLOOD CLEARANCE OF ^<99m>Tc-PHYTATE FOR EVALUATION OF HEPATIC DYSFUNCTION IN DOGS
- Direct Comparison of Fine Structure on Ti L_3 Threshold by Disappearance Potential and Auger Electron and Soft X-Ray Appearance Potential Spectroscopies
- Adenoid Cystic Carcinoma of the Esophagus : Report of a Case and Review of the Japanese Literature
- Relationship of Serum Lipids to 10-year Deaths from All Causes and Cancer in Japanese Urban Dwellers Aged 40 Years and Over
- Self-rated Health as a Predictor of Active Life in the Community Elderly
- α-ナフチルイソチオシアン酸肝障害ラットにおける99mTc-フィチン酸とインドシアニングリ-ンの血液クリアランス試験の比較〔英文〕
- Impact Response Analysis of Patella-Patellar Tendon-Tibial Tuberosity Complex(Impact 2)
- Analysis of Compression Force in the Hip Joint during Impulsive Exercises: A Preliminary Study for Developing Exercise Protocol for Osteoporosis
- Relationship of Serum Cholesterols and Vitamin E to Depressive Status in the Elderly
- Longitudinal Change in Serum Cholesterol Levels Among Isolated Hypertriglyceridemic Cases
- Health Problems in Aging Populations
- Dynamic Scaling Laws for the Intermittent Switching between Two Bands : Progress Letters
- Usefulness of assessing masked and white-coat hypertension by ambulatory blood pressure monitoring for determining prevalent risk of chronic kidney disease : the Ohasama study
- Reciprocal Expression of mRNA for Inhibin β_C and β_A Subunits in Hepatocytes
- EFFECT OF α-NAPHTHYLISOTHIOCYANATE ON BLOOD CLEARANCE OF ^<99m>Tc-PHYTATE IN RATS
- Characteristic Property of Impact Fracture Toughness
- Microtubule Disruption with BAPTA and Dimethyl BAPTA by a Calcium Chelation-Independent Mechanism in 3T3-L1 Adipocytes
- Decreased expression of adrenomedullin 2/intermedin in the kidney of hypertension or renal failure ; Possible involvement in chronic kidney disease
- BLOOD CLEARANCE OF ^<99m>Tc-PHYTATE FOR EVALUATION OF HEPATIC DYSFUNCTION IN RATS
- EFFECT OF D-GALACTOSAMINE ON BLOOD CLEARANCE OF ^<99m>Tc-PHYTATE IN RATS
- EFFECT OF D-GALACTOSAMINE ON BLOOD CLEARANCE OF ^Tc-PHYTATE IN DOGS
- EFFECT OF α-NAPHTHYLISOTHIOCYANATE ON BLOOD CLEARANCE OF ^<99m>Tc-PHYTATE IN DOGS
- EFFECT OF DL-ETHIONINE ON BLOOD CLEARANCE OF ^Tc-PHYTATE IN DOGS
- New Asymptotic Law Governing Overall Temporal Correlations in Chaotic Systems : Ensemble Homogenization and Order-q Power Spectrum : General and Mathematical Physics
- Correlation Length in the Rayleigh-Benard Convection(General)
- BLOOD CLEARANCES OF ^Tc-PHYTATE AND INDOCYANINE GREEN IN CARBON TETRACHLORIDE TREATED DOGS
- Molluscan faunas of the First Setouchi Series, Southwest Japan Part l : Fauna of the Ichishi Group
- EFFECTS OF HYPERTENSION AND ANTIHYPERTENSIVE DRUGS ON CARDIOVASCULAR COMPLICATIONS IN THE ELDERLY
- Virucidal Activity of Alcohol-Based Hand Rub Disinfectants
- Bactericidal Effects and Cytotoxicity of New Aromatic Dialdehyde Disinfectants (Ortho-phthalaldehyde)
- Corrosive effect of disinfection solution containing hydroxyl radicals generated by photolysis of H_2O_2 on dental metals
- Congenital Heart Disease in High School and College Students
- Induction of prolonged elevation of interleukin 2 in the culture medium of murine splenocytes by their precultivation before mitogenic stimulations and its potentiation by glucocorticoid treatment and restraint stress loading.
- Comprehensive Study of Elderly People Living in an Urban Community: The Koganei Study
- New evidence about thyroid cancer prevalence : prevalence of thyroid cancer in younger and middle-aged Japanese population