EFFECT OF D-GALACTOSAMINE ON BLOOD CLEARANCE OF ^<99m>Tc-PHYTATE IN RATS

概要

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The effect of D-galactosamine (GalN) on the blood clearance of ^<99m>Tc-phytate (^<99m>Tc-P) in rats was examined, and the blood clearance test of ^<99m>Tc-P was compared with the cases of serum transaminase and bilirubin test. Serum transaminase and bilirubin levels in rats increased dosedependantly after GalN administration. The disappearance rate of ^<99m>Tc-P from blood decreased with the increase in dose of GalN and with the passage of time after the GalN administration. Changes of the blood clearance of ^<99m>Tc-P after GalN treatment in rats may be influenced by the disorder in the hepatocytes and the alteration of the liver reticuloendothelial system phagocytic function. The blood clearance test of ^<99m>Tc-P in rats showed a sensitive reaction for the acute hepatic dysfunction induced by GalN equally to or higher than the serum transaminase and bilirubin test.
日本トキシコロジー学会の論文
1989-08-25