BLOOD CLEARANCES OF ^<99m>Tc-PHYTATE AND INDOCYANINE GREEN IN CARBON TETRACHLORIDE TREATED DOGS

概要

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The comparative study of the blood clearances of ^<99m>Tc-phytate (^<99m>Tc-P) and indocyanine green (ICG) was carried out in dogs with hepatic injury induced by carbon tetrachloride (CCl_4), and the blood clearance of ^<99m>Tc-P or ICG was compared with the levels of serum transaminase and bilirubin. The blood clearances of ^<99m>Tc-P and ICG in dogs decreased with increase in doses of CCl_4 and with elapsed time after CCl_4 administration. The decreases were correspondent to the increase in serum transaminase activity and bilirubin level. The blood clearance test of ^<99m>Tc-P in dogs showed a equal degree of sensitivity and a higher degree of accuracy for the acute hepatic dysfunction induced by CCl_4 as compared with the blood clearance test of ICG.
日本トキシコロジー学会の論文
1991-11-25