ISOLATION OF MYCOLIC ACID-CONTAINING GLYCOLIPIDS IN NOCARDIA RUBRA AND THEIR GRANULOMA FORMING ACTIVITY IN MICE
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概要
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Three classes of glycolipids (TMM (trehalose monomycolate), TDM (trehalose dimycolate) and GM (glucose mycolate)) containing mycolic acids as hydrophobic components were isolated from a strain of Nocardia rubra (Rhodococcus rubrum) and their structures have been partially characterized using infrared spectrometry, gas-liquid chromatography and gas chromatography-mass spectrometry. Acid or alkaline hydrolysis of isolated glycolipids revealed that trehalose was the sole water soluble component in TMM and TDM, while glucose was the hydrophilic component in GM. On the other hand, saturated, monoenoic and dienoic mycolic acids with carbon atoms ranging from C_<36> to C_<50> contained constituents of fatty acid moiety at C_<44>. From the analytical results, TMM, TDM and GM were tentatively identified as trehalose monomycolate, trehalose dimycolate and glucose monomycolate, respectively. The mycolic acid composition differed significantly by the glycolipid classes : the highest amount of saturated mycolic acids were detected in TMM and GM, while a significant amount of dienoic mycolic acids have been found in TDM and the cell wall bound lipid fraction (BL). All these three classes of glycolipids containing mycolic acids showed strong granuloma forming activity in lungs and spleen of ICR mice 1 week after intravenous injection of 100 to 500 μg glycolipid in W/O/W micelles containing Freund's incomplete adjuvant. These results indicated that glycolipids containing shorter carbon chain mycolic acids ranging C_<40-50>, corresponding to less acyl numbers or monosaccharides such as glucose, can also produce foreign body-type granuloma in mice without protein antigens.
- 社団法人日本薬学会の論文
著者
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KANEDA Kenji
Department of Anatomy, Osaka City University Medical School
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Kaneda Kenji
クラブコスメチックス
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Kaneda K
Osaka City Univ. Medical School
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YANO IKUYA
Department of Bacteriology, Osaka City University Medical School
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TOMIYASU IKUKO
Department of Bacteriology, Osaka City University Medical School
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KATO YOSHIKO
Department of Bacteriology, Osaka City University Medical School
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SUMI YUKIE
Department of Bacteriology, Osaka City University Medical School
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KURANO SATOKO
Department of Bacteriology, Osaka City University Medical School
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SUGIMOTO NOBUKO
Department of Bacteriology, Osaka City University Medical School
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SAWAI HIROYUKI
Department of Bacteriology, Osaka City University Medical School
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Sumi Yukie
Department Of Bacteriology Osaka City University Medical School:tezukayama Junior College:department
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Kurano Satoko
Department Of Bacteriology Osaka City University Medical School:tezukayama Junior College:department
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Sugimoto Nobuko
Department Of Bacteriology Osaka City University Medical School:tezukayama Junior College:department
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Kato Y
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Tomiyasu Ikuko
大阪市立大学 細菌
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Tomiyasu Ikuko
Department Of Bacteriology Osaka City University Medical School:tezukayama Junior College:department
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YANO Ikuko
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
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Sawai Hiroyuki
Department Of Bacteriology Osaka City University Medical School:tezukayama Junior College:department
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Kaneda Kenji
Department Of Bacteriology Niigata University School Of Medicine
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Kimura Koichi
Department Of Microbiology
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Kaneda Kenji
Department Of Anatomy Osaka City University Medical School
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Yano Ikuya
Department Of Bacterilogy Osaka City University Medical School
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Yano I
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Kaneda K
Department Of Food Science Shizuoka Eiwa Gakuen University Junior College
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Kaneda Kenji
Department Of Anatomy Osaka City University Graduated School Of Medicine
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