Serotype-Specific Modulation of Human Monocyte Functions by Glycopeptidolipid (GPL) Isolated from Mycobacterium avium Complex(Miscellaneous)
スポンサーリンク
概要
- 論文の詳細を見る
Immunomodulating activity of glycopeptidolipids (GPL), separated from different serovars of Mycobacterium avium complex (MAC), on macrophage functions was compared. When peripheral blood mononuclear cells (PBMC), from healthy donors showing strongly positive reactions to mycobacterial purified protein derivatives (PPD), were incubated with heat-killed Staphylococcus aureus coated with GPL serovar 4, phagocytosis of monocytes increased in dose-dependent manner. However, coating with GPL serovar 9 did not show any effects. After phagocytosis of heat-killed S. aureus, the phagosome-lysosome (P-L) fusion in monocytes was inhibited dose-dependently by coating of S. aureus with GPL serovar 4, but not serovar 9. These results indicate that GPL serovar 4 facilitates invasion of MAC into monocytes and renders resistance to bactericidal reactions due to the inhibition of P-L fusion. Regarding accessory function of macrophages in proliferative responses of T cells, the addition of GPL serovar 4 to cultures resulted in significant inhibition of anti-CD3 monoclonal antibody (mAb)-induced proliferation, whereas both serovar GPLs did not cause reduction of cell viability. Furthermore, the PPD-specific T cell proliferative response was downregulated markedly by GPL serovar 4, but weakly suppressed by GPL serovar 9. These results indicated that the immunomodulating activity of GPL on macrophage functions is serovar-dependent.
- 公益社団法人日本薬学会の論文
- 2005-02-01
著者
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TAKIMOTO Hiroaki
Department of Virology, Kyushu University
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YANO Ikuya
Japan BCG Laboratory
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Yano I
Osaka City Univ. Medical School Osaka Jpn
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Yano Ikuya
クラブコスメチックス
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Komatsu H
Department Of Medical Oncology And Immunology Nagoya City University Graduate School Of Medical Scie
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Komatsu Hirokazu
名古屋市立大学 医学研究科腫瘍･免疫内科学
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KIYOI Hitoshi
Nagoya University Hospital
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Yano I
Japan Bcg Lab. Tokyo Jpn
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Yano I
Department Of Bacteriology Osaka City University Medical School
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Kano Hideyuki
Department Of Agricultural And Resource Economics Faculty Of Agriculture Kyushu University
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Kano Hideyuki
Department Of Bioscience School Of Science And Graduate School Of Fundamental Life Science Kitasato
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Komatsu Hirokazu
Second Department Of Internal Medicine Nagoya City University School Of Medicine
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Kiyoi Hitoshi
Department Of Infectious Diseases Nagoya University School Of Medicine
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FUJITA Yukiko
Japan BCG Laboratory
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Takimoto Hiroaki
Department Of Bioscience School Of Science And Graduate School Of Fundamental Life Science Kitasato
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Takimoto Hiroaki
Department Of Biology Graduate School Of Science Osaka City University
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KUMAZAWA Yoshio
Department of Bioscience, School of Science and Graduate School of Fundamental Life Science, Kitasat
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DOI Takeshi
Japan BCG Laboratory
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Kanoh Hideyuki
Department Of Gastroenterology Toyokawa City Hospital
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Yano Ikuya
Department Of Bacterilogy Osaka City University Medical School
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Yano Ikuya
Japan Bcg Central Laboratory
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Kuroda Hiroyuki
Laboratory Of Chemotherapy Aichi Cancer Center Research Institute
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KUMAZAWA Yoshio
Department of Bioscience, School of Science and Graduate School of Fundamental Life Science, Kitasato University
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DOI Takeshi
Japan Atomic Energy Research Institute
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