A Citrus Flavonoid Hesperidin Suppresses Infection-Induced Endotoxin Shock in Mice (Miscellaneous)
スポンサーリンク
概要
- 論文の詳細を見る
Administration of a citrus flavonoid hesperidin (HES) to mice before LPS challenge significantly reduced tumor necrosis factor (TNF)-α production in a dose-dependent manner. Treatment of HES 3 h before intraperitoneal (i.p.) infection with 10^8 CFU Salmonella typhimurium aroA resulted in rescue from lethal shock as similar to LPS-nonresponder mice. Not only bacterial numbers in livers and spleens but also plasma LPS levels significantly decreased by pretreatment with HES. In addition, HES markedly suppressed plasma levels of TNF-α and high mobility group box chromosomal protein 1 (HMGB-1), decreased the number of apoptotic cells in livers and normalized the activated states of blood coagulation factors such as prothrombin time and platelet numbers caused by infection. Pretreatment of LPS with HES suppressed the chromogenic Limulus reaction.
- 2004-05-01
著者
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KAWAGUCHI Kiichiro
Medicinal Plant Garden, School of Pharmaceutical Sciences, Kitasato University
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MORITA Hiroyuki
Mitsubishi Kagaku Institute of Life Sciences (MITILS)
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KUMAZAWA Yoshio
Department of Bioscience, School of Science and Graduate School of Fundamental Life Science, Kitasat
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MORITA Hiroyuki
Seikagaku Corporation
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HASUNUMA Ryoichi
Department of Biosciences, School of Science and Graduate School for Fundamental Life Science, Kitas
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Maruyama Hiroko
Department Of Pathology Kitasato University School Of Allied Health Sciences
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Maruyama Hiroko
Department Of Pathology Kitasato University School Of Allied Health Science
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Maruyama H
日本大学総合臨床獣医学研究室
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KIKUCHI Sei-ichi
Medicinal Plant Garden, School of Pharmaceutical Sciences, Kitasato University
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YOSHIKAWA Takafumi
Medicinal Plant Garden, School of Pharmaceutical Sciences, Kitasato University
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Hasunuma Ryoichi
Department Of Biosciences School Of Science And Graduate School For Fundamental Life Science Kitasat
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Kawaguchi K
Medicinal Plant Garden School Of Pharmaceutical Sciences Kitasato University
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Yoshikawa Takafumi
Medicinal Plant Garden School Of Pharmaceutical Sciences Kitasato University:department Of Phytochem
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Kikuchi Sei-ichi
Medicinal Plant Garden School Of Pharmaceutical Sciences Kitasato University
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Kumazawa Y
Department Of Biosciences School Of Science And Graduate School For Fundamental Life Science Kitasat
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Kawaguchi Kiichiro
Medicinal Plant Garden School Of Pharmaceutical Science Kitasato University
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Morita Hiroyuki
School Of Pharmaceutical Science University Of Shizuoka
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