Prolongation of Antidiuretic Response to desmopressin Acetate by Iontophoretic Transdermal Delivery in Rats
スポンサーリンク
概要
- 論文の詳細を見る
An iontophoretic drug delivery system was compared with intranasal, oral and subcutaneous delivery from a standpoint of the prolongation of the antidiuretic response to desmopressin acetate (DDAVP) in diabetes insipidus rats. Iontophoretic delivery was comparable to the nasal route at a dose about five higher than the nasal route dose, and was 2 to 3 times as effective as the oral route. Effect of dose and duration of current application on the prolongation of the response to DDAVP was also investigated in order to find the effectiveness of the iontophoresis. The antidiuretic response to DDAVP delivered by iontophoresis indicated a dose-dependent prolongation and was prolonged up to about 14 h with the increase of the duration of current application; when a pulsed direct current at 0.1 mA was passed for about 1 h, the response to DDAVP was prolonged for about 9 h. DDAVP in the anodic donor steeply decreased with the application for 1 h, and the gradually decreased. We suggest that the antidiuretic response to DDAVP can be effectively controlled by regulating the absorption of DDAVP at the short-term iontophoresis eather than prolonged treatment.
- 公益社団法人日本薬学会の論文
- 1997-05-15
著者
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Kato Y
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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ITO Kunio
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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Ito Kunio
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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KATO Yasuki
Drug Formulation Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd.
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KATO Yasuki
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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Kato Yasuki
協和醗酵工業
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NAKAKURA Masashi
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.,
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Ito K
Janssen Pharmaceutical K.k. Shizuoka Jpn
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Kato Yasuki
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Nakakura M
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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