Evaluation of the Carrier Potential for the Lipid Dispersion System with Lipophilic Compound
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概要
- 論文の詳細を見る
KW-3902 (a newly synthesized adenosine A_1-receptor antagonist) has potent diuretic and renal protective activities and was formulated in lipid dispersion systems, i.e., lipid emulsions and liposomes. The objective of the present study was to evaluate the carrier potential of these lipid dispersion systems, which is explained here as the ability of the formulation to retain the drug in its dispersed phase. The relative affinity of the drug to the formulation, K_<f/b>, was defined as a parameter in order to assess the performance of the formulations and was obtained from the in vitro blood component binding study. The results indicated that KW-3902 showed higher relative affinity to the liposome formulation than to the lipid emulsion. Moreover, the total amount of drug retained in the dispersion system depended on both K_<f/b> and the dosing volume. The usefulness of the parameter, K_<f/b>, was discussed as an indicator for a carrier potential to understand the properties of the formulations.
- 公益社団法人日本薬学会の論文
- 2003-07-01
著者
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Kato Y
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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Yamauchi M
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Yamauchi M
School Of Engineering Kinki University
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Iwata Kenji
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Yamauchi Masahiro
Pharmaceutical Research Center, KYOWA HAKKO KOGYO CO., LTD.
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KATO Yasuki
Drug Formulation Research Laboratories, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co., Ltd.
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HOSOKAWA Toshihito
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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YAMAMOTO Yoshihiko
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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NAKAMURA Akimasa
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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KATO Yasuki
Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd.
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岩田 建
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Okayama University
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Kato Yasuki
協和醗酵工業
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Yamamoto Yoshihiko
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Kato Yasuki
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Yamamoto Yoshihiko
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Yamauchi Masahiro
Pharmaceutical Research Center Kyowa Hakko Kogyo Co. Ltd.
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Hosokawa T
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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Nakamura Akimasa
Pharmaceutical Research Institute Kyowa Hakko Kogyo Co. Ltd.
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