Biological Fate of Highly-Succinylated N-Succinyl-chitosan and Antitumor Characteristics of Its Water-soluble Conjugate with Mitomycin C at I.v. and I.p. Administration into Tumor-Bearing Mice
スポンサーリンク
概要
- 論文の詳細を見る
Highly-succinylated N-succinyl-chitosan (Suc) was fluorescein-labeled, and the labeled product (Suc-FTC) was examined for biodisposition in Sarcoma 180-bearing mice after i.v. and i.p. administration. Suc-FTC injected intravenously was sustained at a high level in the blood circulation and showed little distribution to tissues other than tumor. On the other hand, it took a few hours for Suc-FTC to be transferred to the blood circulation after i.p. administration. There were no marked differences in the distribution of Suc-FTC between i.v. and i.p. administration routes except in the early stage. The urinary excretion of Suc-FTC following both i.v. and i.p. administration was small, but the excretion tended to be suppressed after i.p. administration. Water-soluble Sucmitomycin C conjugate (Suc-MMC) prepared using water-soluble carbodiimide exhibited marked effect at a high dose and suppressed the acute toxic side effect of MMC. Suc-MMC tended to be more toxic at i.p. administration that at i.v. administration. The difference in biodisposition between the two administrations was thought to affect the toxic side effect. The plasma levels of conjugated and free MMCs at 8 h after i.v. administration were higher than those at 8 h after i.p. administration. These suggested more localization of the conjugate in peripheral tissues and less excretion at i.p. administration, which might result in greater toxicity.
- 公益社団法人日本薬学会の論文
- 2000-12-01
著者
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ONISHI Hiraku
Department of Drug Delivery Research, Hoshi University
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MACHIDA Yoshiharu
Department of Drug Delivery Research, Hoshi University
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Kato Y
Institute Of Cosmetic Sciences Club Cosmetics Co. Ltd.
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KATO Yoshinori
Department of Pharmaceutical Sciences, Tohoku University Hospital and Division of Clinical Pharmacy,
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Onishi Hiraku
Department Of Drug Delivery Research Hoshi University
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Onishi Hiraku
Department Of Clinical Pharmacy Hoshi University
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Kato Y
Department Of Drug Delivery Research Hoshi University
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Machida Yoshiharu
Department Of Drug Delivery Research Hoshi University
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Machida Yoshiharu
Dep. Of Drug Delivery Res. Hoshi Univ.
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Machida Yoshiharu
Department Of Clinical Pharmacy Hoshi University
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Kato Yoshinori
Department Of Civil Engineering Maizuru National College Of Technology
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