Preparation and Evaluation of Novel Directly-Compressed Fast-Disintegrating Furosemide Tablets with Sucrose Stearic Acid Ester
スポンサーリンク
概要
- 論文の詳細を見る
Fast-disintegrating tablets of furosemide (FS) were prepared by the novel direct compression method. FS, microcrystalline cellulose (MC), croscarmellose sodium (CC), xylitol (XL) and sucrose stearic acid esters (SSEs) with an hydrophilic–lipophilic balance (HLB) of 16, 15 and 11, named S1670, S1570 and S1170, were used. An FS/SSE/MC mixed powder was obtained by solvent evaporation of a suspension of MC in ethanol solution containing FS and SSE, and the resultant mixed powder was mixed with CC and XL, and directly compressed. The tablets with hardness of more than 40 N and disintegration time of less than 20 s were obtained at the addition of SSE at 0—0.5% (w/w). A tablet with S1670 at 0.1% (w/w), named TA2, dissolved faster than a commercial FS tablet, Lasix. TA2 tended to show higher plasma concentration than Lasix after intragastric administration to rats. It was demonstrated that the present direct compression using homogeneous FS/S1670/MC powder mixture could give an excellent fast-disintegrating tablet of FS.
著者
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KOSEKI Takuma
Department of Drug Delivery Research, Hoshi University
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ONISHI Hiraku
Department of Drug Delivery Research, Hoshi University
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TAKAHASHI Yuri
Department of Drug Delivery Research, Hoshi University
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UCHIDA Minoru
Market Development Department, Mitsubishi-kagaku Foods Corporation
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MACHIDA Yoshiharu
Department of Drug Delivery Research, Hoshi University
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Takayama K
Hoshi Univ. Tokyo Jpn
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Takayama Kozo
Department Of Pharmaceutics Faculty Of Pharmaceutical Sciences Hoshi University
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Uchida Minoru
Market Dev. Dep. Mitsubishi-kagaku Foods Corp.
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Onishi Hiraku
Department Of Clinical Pharmacy Hoshi University
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Machida Yoshiharu
Department Of Clinical Pharmacy Hoshi University
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Takahashi Yuri
Department Of Bioresource Engineering Faculty Of Agriculture Yamagata University
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Uchida Minoru
Market Development Department, Mitsubishi-Kagaku Foods Corp.
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