In Vivo Evaluation of Kumazasa Extract and Chitosan Films Containing the Extract against Deep Skin Ulcer Model in Rats(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
Kumazasa extract (KE) and its whole solid component (EXT)-containing chitosan films produced by drying in air and lyophilization, abbreviated to ND and FD films, respectively, were examined for efficacy and healing features using a deep skin ulcer model in rats. Their effects were compared with those of clinically available dosage forms, Beschitin^[○!R] W, Geben^[○!R] cream and U-PASTA. KE alone exhibited a better effect as compared with other preparations, and FD films also more effective than control in the early stage. Histological analysis showed that KE alone reduced necrosis rapidly and accelerated granulation. ND films delayed healing rate as compared with control. FD films showed histological features between control and KE alone, but tended to delay healing rate in the later period. Thus, reduction rate of wound area and histological features suggested that KE alone should be excellent for the promotion of wound healing. Although FD films were less effective than KE alone, they were superior as to usability such as changing the preparation.
- 2007-12-01
著者
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ONISHI Hiraku
Department of Drug Delivery Research, Hoshi University
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MACHIDA Yoshiharu
Department of Drug Delivery Research, Hoshi University
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TAKESHITA Kazuo
Hoshi Pharmaceutical Company
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Isowa Koichi
Jbs Inc.
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Onishi Hiraku
Department Of Clinical Pharmacy Hoshi University
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HIROSE Kaori
Department of Drug Delivery Research, Hoshi University
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SASATSU Masanaho
Department of Drug Delivery Research, Hoshi University
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KOUZUMA Kazuto
Hoshi Pharmaceutical Co., Ltd.
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Takeshita Kazuo
Hoshi Pharmaceutical Co. Ltd.
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Hirose Kaori
Department Of Drug Delivery Research Hoshi University
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Kouzuma Kazuto
Hoshi Pharmaceutical Co. Ltd.
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Machida Yoshiharu
Department Of Drug Delivery Research Hoshi University
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Machida Yoshiharu
Dep. Of Drug Delivery Res. Hoshi Univ.
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Machida Yoshiharu
Department Of Clinical Pharmacy Hoshi University
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Sasatsu Masanaho
Dep. Of Drug Delivery Res. Hoshi Univ.
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