Prolonged Intestinal Absorption of Cephradine with Chitosan-Coated Ethylcellulose Microparticles in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Cephradine-containing ethylcellulose microparticles (MPC) were prepared by the solvent evaporation method. Chitosan-coated MPC (Chi-MPC) were prepared by doping MPC with viscous chitosan solution and subsequently drying. When fluorescein isothiocyanate (FITC)-labeled chitosan-coated ethylcellulose micropartides without drug were administered intraduodenally, they moved slowly in the intestine, that is, most of them were retained at the upper and middle parts of the small intestine for more than 8 h, which is considered due to mucoadhesive properties of coated chitosan. When MPC and Chi-MPC was incubated at 37℃ in the JP 14 second fluid, pH 6.8, both released the drug slowly with similar release rates. Cephradine solution and suspension, MPC and Chi-MPC were administered intraduodenally to investigate intestinal drug absorption. Only Chi-MPC suppressed the initial plasma level and maintained the plasma concentration for a long time up to 24 h, suggesting Chi-MPC would be useful for prolonged intestinal absorption of cephradine.
- 公益社団法人日本薬学会の論文
- 2002-11-01
著者
-
Onishi H
Department Of Drug Delivery Research Hoshi University
-
Onishi Hiraku
Department Of Clinical Pharmacy Hoshi University
-
Machida Y
Department Of Drug Delivery Research Hoshi Universily
-
Machida Yoshiharu
Department Of Clinical Pharmacy Hoshi University
-
TAKISHIMA Junko
Department of Drug Delivery Research, Hoshi Universily
-
Takishima Junko
Department Of Drug Delivery Research Hoshi Universily
関連論文
- Preparation and Evaluation of Novel Directly-Compressed Fast-Disintegrating Furosemide Tablets with Sucrose Stearic Acid Ester
- Development of Novel Fast-Disintegrating Tablets by Direct Compression Using Sucrose Stearic Acid Ester as a Disintegration-Accelerating Agent
- Preparation and Evaluation of Medicinal Carbon Tablets with Different Saccharides as Binders
- Medicinal Carbon Tablets for Treatment of Acetaminophen Intoxication : Adsorption Characteristics of Medicinal Carbon Powder and Its Tablets
- In Vivo Evaluation of Kumazasa Extract and Chitosan Films Containing the Extract against Deep Skin Ulcer Model in Rats(Biopharmacy)
- Influence of Flushing Conditions on Incompatibility in Y-site Injection (Second report) : Survey and Evaluation Flushing Conditions at Medical Institutions
- Enhancing Effect of Switching Iontophoresis on Transdermal Absorption of Sodium Benzoate In Vivo
- Biological Fate of Highly-Succinylated N-Succinyl-chitosan and Antitumor Characteristics of Its Water-soluble Conjugate with Mitomycin C at I.v. and I.p. Administration into Tumor-Bearing Mice
- Quantitative Evaluation for the Endotoxin Adsorption-Ability of Medicinal Carbon
- Antitumor Characteristics of Poly (d, l-lactic acid-co-glycolic acid) Copolymer Implant Tablets Containing Irinotecan Hydrochloride (CPT-11)
- Effect of Penetration Enhancers on Transdermal Delivery of Propofol(Biopharmacy)
- An Automatic Ampoule Dispensing System Improved Injection Dispensing
- PLGA Implant Tablet of Ketoprofen : Comparison of in Vitro and in Vivo Releases(Biopharmacy)
- Preparation of Quickly Disintegrating Glucose Tablets for Treatment of Hypoglycemia and Analysis of Factors Influencing the Characteristics of the Tablets
- Influence of Pectins on Preparation Characteristics of Lactoferrin Bioadhesive Tablets
- Preparation and Characterization of an Aqueous Suspension Containing Nanoparticles of Poly (DL-lactic Acid)/Irinotecan/Polyethylene Glycol Monostearate
- Prolonged Intestinal Absorption of Cephradine with Chitosan-Coated Ethylcellulose Microparticles in Rats
- Effect of Iontophoresis and Switching Iontophoresis on Skin Accumulation of Ketoprofen(Biopharmacy)
- Transdermal Absorption of Propofol in Rats(Biopharmacy)
- Biodisposition Characteristics of N-Succinyl-chitosan and Glycol-chitosan in Normal and Tumor-bearing Mice
- Preparation of Double Liposomes and Their Efficiency as an Oral Vaccine Carrier(Biopharmacy)
- Antitumor Properties of Irinotecan-Containing Nanoparticles Prepared Using Poly(DL-lactic acid) and Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)(Biopharmacy)
- Antitumor Activities of Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol via Glutaric Acid in Suspension Dosage Form(Biopharmacy)
- In Vivo Properties of the Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol : Pharmacokinetics and Antitumor Characteristics against P388 Leukemia and Sarcoma 180
- Biological Properties of Conjugates of Mitomycin C with Estradiol Benzoate and Estradiol : Their Stability Characteristics in Biological Media and Their Binding Abilities to Estrogen Receptor
- Conversion Characteristics of the Conjugates of Mitomycin C with Estradiol and Estradiol Benzoate in Various pH Media
- Stability of Spironolactone in Rat Plasma : Strict Temperature Control of Blood and Plasma Samples Is Required in Rat Pharmacokinetic Studies(Biopharmacy)
- Preparation and Evaluation of Medicinal Carbon Oral Films
- In Vitro and in Vivo Evaluation of Sustained Release Chitosan-Coated Ketoprofen Microparticles
- Conjugate between Chondroitin Sulfate and Prednisolone with a Glycine Linker: Preparation and in Vitro Conversion Analysis