Multidrug Resistance in Klebsiella pneumoniae MGH78578 and Cloning of Genes Responsible for the Resistance(Microbiology)
スポンサーリンク
概要
- 論文の詳細を見る
Klebsiella pneumoniae MGH78578, a clinical isolate, showed high level of resistance to many antimicrobial agents. We cloned genes responsible for drug resistance from chromosomal DNA of K. pneumoniae MGH78578 by shotgun method using Escherichia coli KAM32, a drug hypersensitive strain, as host. We obtained 43 hybrid plasmids that made host cells resistant to several antimicrobial agents. We classified them into 17 groups based on growth properties in the presence of each one of 9 antimicrobial agents and on restriction patterns of each hybrid plasmid. Analysis of the cloned genes must be very useful for investigation of major parts of multidrug resistance systems including multidrug efflux pumps in K. pneumoniae MGH78578 in which genome sequence is available.
- 社団法人日本薬学会の論文
- 2005-08-01
著者
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OGAWA Wakano
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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KURODA Teruo
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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TSUCHIYA Tomofusa
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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Tsuchiya T
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Tsuchiya Tomofusa
岡山大学 分子微生物学
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Kuroda T
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Kuroda Teruo
岡山大学 分子微生物学
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Ogawa Wakano
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Ogawa Wakano
岡山大学 分子微生物学
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Ogawa Wakano
Department Of Microbiology Faculty Of Pharmaceutical Sciences Okayama University
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Mizushima Tohru
Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
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LI Dai-Wei
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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YU PING
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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BEGUM Anowara
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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LI Dai
Department of Molecular Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Scie
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Li Dai
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Li Dai-wei
岡山大学 医歯薬学総合研究科分子微生物学教室
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Mima Takehiko
岡山大学 医歯薬学総合研究科
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Tsuchiya Tomofusa
Department Of Microbiology Faculty Of Pharmaceutical Sciences Okayama University
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Kayahara Takashi
Department Of Microbiology Faculty Of Pharmaceutical Sciences Okayama University
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Yu Ping
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Begum Anowara
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Begum Anowara
Department Of Microbiology University Of Dhaka
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Kuroda T
Faculty Of Pharmaceutical Sciences Fukuoka University
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Mizushima Tohru
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Mizushima Tohru
Graduate School Of Medical And Pharmaceutical Sciences Kumamoto University
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Li Dai
Department Of Dermatology Xiangya Hospital Central South University
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Kuroda Teruo
Department Of Microbiology Faculty Of Pharmaceutical Science Okayama University
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Tanabe Tomotaka
College Of Pharmaceutical Sciences Matsuyama University
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Yu Ping
Department of Materials Science, Sichuan University, Chengdu 610064, China
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Kuroda Teruo
Department of Genome Applied Microbiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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