Effects of Sucralfate on Gastric Irritant-Induced Necrosis and Apoptosis in Cultured Guinea Pig Gastric Mucosal Cells(Biochemistry/Molecular Biology)
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概要
- 論文の詳細を見る
We previously reported that several gastric irritants, including ethanol, hydrogen peroxide, and hydrochloric acid, induced both necrosis and apoptosis in cultured gastric mucosal cells. In the present study, we examined the effects of sucralfate, a unique gastroprotective drug, on gastric irritant-induced necrosis and apoptosis produced in vitro. Sucralfate strongly inhibited ethanol-induced necrosis in primary cultures of guinea pig gastric mucosal cells. The preincubation of cells with sucralfate was not necessary for its cytoprotective effect to be observed, thus making its mechanism of action different from that of other gastroprotective drugs. Necrosis of gastric mucosal cells induced by hydrogen peroxide or indomethacin was also suppressed by sucralfate. On the other hand, sucralfate only weakly inhibited ethanol-induced apoptosis. These results suggest that the cytoprotective effect of sucralfate on gastric mucosa in vivo can be explained, at least in part, by its inhibitory effect on gastric irritant-induced necrosis.
- 公益社団法人日本薬学会の論文
- 2003-01-01
著者
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土屋 照雄
Gifu Prefectural Hospital
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Tsuchiya Tomofusa
岡山大学 薬学部
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Tsuchiya Tomofusa
Faculty Of Pharmaceutical Sciences Okayama University
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Mizushima Tohru
Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
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Mima Takehiko
岡山大学 医歯薬学総合研究科
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Miki T
Faculty Of Pharmaceutical Sciences Kyushu University
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HOSHINO Tyuji
Department of Physical Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University
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Tsuchiya T
Faculty Of Pharmaceutical Sciences Okayama University
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Tsuchiya T
Okayama Univ. Okayama
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Hoshino T
Department Of Physical Chemistry Graduate School Of Pharmaceutical Sciences Chiba University
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Hoshino Tyuji
Department Of Physical Chemistry Graduate School Of Pharmaceutical Sciences Chiba University
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TOMISATO Wataru
Faculty of Pharmaceutical Sciences, Okayama University
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TSUTSUMI Shinji
Faculty of Pharmaceutical Sciences, Okayama University
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HOSHINO Tatsuya
Faculty of Pharmaceutical Sciences, Okayama University
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MIZUSHIMA Tohru
Faculty of Pharmaceutical Sciences, Okayama University
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TAKANO Tatsunori
Faculty of Pharmaceutical Sciences, Okayama University
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HWANG Hyun-Jung
Faculty of Pharmaceutical Sciences, Okayama University
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KOURA Yuko
Faculty of Pharmaceutical Sciences, Okayama University
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NISHIMOTO Kiyo
Faculty of Pharmaceutical Sciences, Okayama University
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Nishimoto Kiyo
Faculty Of Pharmaceutical Sciences Okayama University
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Koura Yuko
Faculty Of Pharmaceutical Sciences Okayama University
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Tsuchiya T
Faculty Of Pharmaceutical Sciences Hokuriku University
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Mizushima Tohru
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Mizushima Tohru
Faculty Of Pharmaceutial Sciences Kyushu University
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Mizushima Tohru
Faculty Of Engineering. Tokai University
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Hwang Hyun-jung
Faculty Of Pharmaceutical Sciences Okayama University
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Tomisato Wataru
Faculty Of Pharmaceutical Sciences Okayama University
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Tsutsumi S
Faculty Of Pharmaceutical Sciences Okayama University
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Tsuchiya Tomofusa
Department Of Microbiology Fujita Health University
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Tsutsumi Shinji
Faculty Of Pharmaceutical Sciences Okayama University
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Takano Tatsunori
Faculty Of Pharmaceutical Sciences Okayama University
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Mizushima T
Faculty Of Pharmaceutial Sciences Kyushu University
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Mizushima Tohru
Faculti of Pharmaceutical Sciences Okairama University
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