Geranylgeranylacetone Suppresses Spontaneous Apoptotic DNA Fragmentation in Cultured Guinea Pig Gastric Pit Cells
スポンサーリンク
概要
- 論文の詳細を見る
We recently found that guinea pig gastric pit cells in culture undergo spontaneous and rapid apoptotic DNA fragmentation, which may represent the rapid death of gastric pit cells in vivo. In this study, we observed that pretreatment of cells with geranylgeranylacetone, an antiulcer drug with heat-shock protein-inducing activity, suppressed the spontaneous apoptotic DNA fragmentation in a dose-dependent manner. Pretreatment of cells with low concentrations of ethanol or heat-shock also prevented the spontaneous apoptotic DNA fragmentation. These observations indicate that the suppression of the apoptotic DNA fragmentation by geranylgeranylacetone involve the induction of heat-shock proteins.
- 公益社団法人日本薬学会の論文
- 1999-08-15
著者
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土屋 照雄
Gifu Prefectural Hospital
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ROKUTAN Kazuhito
Department of Nutrition, School of Medicine, University of Tokushima
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Tsuchiya Tomofusa
岡山大学 薬学部
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Tsuchiya Tomofusa
Faculty Of Pharmaceutical Sciences Okayama University
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Mizushima Tohru
Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
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Miki T
Faculty Of Pharmaceutical Sciences Kyushu University
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Tsuchiya T
Faculty Of Pharmaceutical Sciences Okayama University
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Tsuchiya T
Okayama Univ. Okayama
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TSUTSUMI Shinji
Faculty of Pharmaceutical Sciences, Okayama University
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MIZUSHIMA Tohru
Faculty of Pharmaceutical Sciences, Okayama University
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Rokutan Kazuhito
Department Of Nutrition School Of Medicine The University Of Tokushima
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Rokutan Kazuhito
Department Of Nutrition University Of Tokushima School Of Medicine
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Tsuchiya T
Faculty Of Pharmaceutical Sciences Hokuriku University
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Mizushima Tohru
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Mizushima Tohru
Faculty Of Pharmaceutial Sciences Kyushu University
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Mizushima Tohru
Faculty Of Engineering. Tokai University
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Tsutsumi S
Faculty Of Pharmaceutical Sciences Okayama University
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Tsuchiya Tomofusa
Department Of Microbiology Fujita Health University
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Tsutsumi Shinji
Faculty Of Pharmaceutical Sciences Okayama University
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Mizushima T
Faculty Of Pharmaceutial Sciences Kyushu University
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Mizushima Tohru
Faculti of Pharmaceutical Sciences Okairama University
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