Long-Term Administration of 4^G-β-D-Galactosylsucrose (Lactosucrose) Enhances Intestinal Calcium Absorption in Young Women : A Randomized, Placebo-Controlled 96-wk Study
スポンサーリンク
概要
- 論文の詳細を見る
This study determined the effect of long-term administration of 4^G-β-D-galactosylsucrose (lactosucrose; LS) on intestinal calcium absorption. In a randomized, singleblind, parallel-group study, LS (n=9, 6.0 g twice daily) or a placebo (maltose; n=8, 6.0 g twice daily) was administered to healthy young women for 92 wk; the study also included a 4-wk post-administration period. All participants completed the study. Dietary nutrient intake; fecal weight, pH, and moisture content; fecal concentrations of short-chain fatty acids (SCFA), putrefactive products, ammonia, and minerals (calcium, magnesium, phosphorus, and iron); and serum calcium and osteocalcin concentrations were measured every 24 wk. Urinary pyridinoline (PYR) and deoxypyridinoline (DPD), and urinary calcium excretion were measured every 12 wk. Significant effects of oligosaccharide treatment, time, and the interaction between oligosaccharide treatment and time were observed for fecal pH, SCFA, ammonia, and putrefactive product values (p<0.05). Fecal pH, ammonia, and putrefactive product values decreased in the LS group, and the fecal SCFA concentration significantly increased during the administration period; these changes were not observed 4 wk post-administration. To examine the mineral balance of calcium, magnesium, and phosphorus in detail, all the participants completed a 6-d mineral balance study, sometime between week 56 and 60 of the longer study. During the mineral balance study, the daily calcium intake was set at 400 mg; all feces and urine were collected each day for 6 d after an 8-d acclimation period. In the balance study, fecal calcium excretion was significantly lower in the LS group than in the placebo group (p<0.05), and apparent calcium absorption and retention, apparent magnesium and phosphorus absorption, and magnesium retention were significantly higher in the LS group than in the placebo group (p<0.05). Our results suggest that the administration of LS produces a long-term enhancement of intestinal calcium absorption in healthy young women with lower than recommended calcium intakes.
著者
-
TERAMOTO Fusako
Department of Clinical Nutrition, Kawasaki University of Medical Welfare
-
ROKUTAN Kazuhito
Department of Nutrition, School of Medicine, University of Tokushima
-
SUGANO Yasuko
Department of Clinical Nutrition, Kawasaki University of Medical Welfare
-
OKU Kazuyuki
Hayashibara Biochemical Laboratories, Inc.
-
KISHINO Eriko
Ensuiko Sugar Refining Co., Ltd.
-
FUJITA Koki
Ensuiko Sugar Refining Co., Ltd.
-
KARA Kozo
Ensuiko Sugar Refining Co., Ltd.
-
KISHI Kyouichi
Department of Nutrition, School of Medicine, University of Tokushima
-
FUKUNAGA Masao
Department of Nuclear Medicine, Kawasaki Medical School
-
MORITA Tetsuro
Department of Clinical Nutrition, Kawasaki University of Medical Welfare
-
Fukunaga Masao
Kawasaki Medical School Okayama Jpn
-
Kara Kozo
Ensuiko Sugar Refining Co. Ltd.
-
Fujita Koki
北海道大学 農学研究院応用生命科学
-
Oku Kazuyuki
Hayashibara Biochemical Laboratories Inc.
-
Kishino Eriko
北海道大学 農学研究院応用生命科学
-
Sugano Yasuko
Department Of Clinical Nutrition Kawasaki University Of Medical Welfare
-
Kishi Kyouichi
Department Of Nutrition School Of Medicine University Of Tokushima
-
Morita Tetsuro
Department Of Clinical Nutrition Faculty Of Medical Professions Kawasaki University Of Medical Welfa
-
HARA Kozo
Ensuiko Sugar Refining Co., Ltd.
-
Rokutan K
Department Of Nutrition School Of Medicine University Of Tokushima
-
Rokutan Kazuhito
Department Of Nutrition School Of Medicine The University Of Tokushima
-
Teramoto Fusako
Department Of Clinical Nutrition Kawasaki University Of Medical Welfare
-
Fukunaga Masao
Department Of Geriatric Medicine Graduate School Of Medicine The University Of Tokyo
-
Morita Tetsuro
Department Of Clinical Nutrition Kawasaki University Of Medical Welfare
関連論文
- Long-Term Administration of 4^G-β-D-Galactosylsucrose (Lactosucrose) Enhances Intestinal Calcium Absorption in Young Women : A Randomized, Placebo-Controlled 96-wk Study
- Biochemical markers for the detection of bone metastasis in parients with prostate cancer: diagnostic efficacy and the effect of hormonal therapy
- Promotion of Bone Formation by Fermented Soybean (Natto) Intake in Premenopausal Women
- Usual Dietary Intake of Fermented Soybeans (Natto) Is Associated with Bone Mineral Density in Premenopausal Women
- Enhancement by Lactosucrose of the Calcium Absorption from the Intestine in Growing Rats
- Standard radial bone mineral density and physical factors in ordinary Japanese women
- Evaluation of Bone Loss and the Serum Markers of Bone Metabolism in Patients with Hyperparathyroidism
- Model-fitting and Prediction of Bone Mineral Density in Postmenopausal Women Using an Exponential-type Nonlinear Mixed-effect Model
- Effect of Estriol on Bone Loss in Postmenopausal Japanese Women : A Multicenter Prospective Open Study
- Efficacy and safety of long-term oral falecalcitriol treatment in patients with renal osteodystrophy
- Preparation and Some Properties of a Novel Maltopentaose-Forming Enzyme of a Pseudomonas species(Microbiology & Fermentation Industry)
- Chemical Characterization of Dextrins Obtained from Potato Starch by Treatment with Bacillus macerans Enzyme
- The Structure of High Molecular Weight Dextrins Obtained from Potato Starch by Treatment with Bacillus macerans Enzyme
- Carbonic anhydrase II was detected in urine of a patient with osteosarcoma during high-dose methotrexate and leucovorin rescue therapy
- Pathological Fracture of the Femur Ten Years after Successful Radiation Therapy for Metastatic Breast Cancer
- MR imaging findings of an unusual case of myositis ossificans presenting as a progressive mass with features of fluid-fluid level
- Effects of Trapidil and Suramin on Growtjh Factor-induced Calcium Response and Tyrosine Phosphorylation in Human Glioma Cells
- Association of a single nucleotide polymorphism in the secreted frizzled-related protein 4 (sFRP4) gene with bone mineral density
- Association of a single-nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 gene with bone mineral density
- The sample size required for intervention studies on fracture prevention can be decreased by using a bone resorption marker in the inclusion criteria : prospective study of a subset of the Nagano Cohort, on behalf of the Adequate Treatment of Osteoporosis
- A comparison of incidences of vertebral fracture in Japanese patients with involutional osteoporosis treated with risedronate and etidronate : a randomized, double-masked trial
- Alendronate reduced vertebral fracture risk in postmenopausal Japanese women with osteoporosis : a 3-year follow-up study
- Absolute height reduction and percent height ratio of the vertebral body in incident fracture in Japanese women
- Diagnostic criteria for primary osteoporosis: year 2000 revision
- A Placebo-Controlled, Single-Blind Study to Determine the Appropriate Alendronate Dosage in Postmenopausal Japanese Patients with Osteopotosis
- Regional Cerebral Blood Flow in the Persistent Vegetative State
- Technetium-99m Methoxyisobutyl Isonitrile Scintigraphy of Bone Metastasis in Three Patients with Differentiated Thyroid Cancer
- Guidelines on the use of biochemical markers of bone turnover in osteoporosis (2001)
- In Vivo Antitumor Activity of Novel Water-Soluble Taxoids(Pharmacology)
- Galactosylation at Side Chains of Branched Cyclodextrins by Various β-Galactosidases
- Geranylgeranylacetone Suppresses Spontaneous Apoptotic DNA Fragmentation in Cultured Guinea Pig Gastric Pit Cells
- Nonenzymatic collagen cross-links induced by glycoxidation (pentosidine) predicts vertebral fractures
- Efficacy and tolerability of once-weekly administration of 17.5mg risedronate in Japanese patients with involutional osteoporosis : a comparison with 2.5-mg once-daily dosage regimen
- Diagnostic criteria of primary osteoporosis
- Nationwide incidence survey of femoral neck fracture in Japan, 1992
- Guidelines for diagnosis and management of Paget's disease of bone in Japan
- Prevalence and clinical features of Paget's disease of bone in Japan
- Synthesis of 2-Deoxy-glucooligosaccharides through Condensation of 2-Deoxy-D-glucose by Glucoamylase and α-Glucosidase
- Fractal Analysis of Bone Architecture at Distal Radius
- Effect of 4^G-β-D-galactosylsucrose (lactosucrose) on fecal microflora in patients with chronic inflammatory bowel disease
- Long-term use of dienogest for the treatment of endometriosis
- Benign Vertebral Accumulation of T^^c-phytate
- Quantification of Bone Mineral in the Vertebral Body and Whole Body Skeleton with a Newly Developed Dual Energy X-ray Absorptiometric System Using a Multi-detector Array
- -0425-ASSESSMENT OF CARDIAC ADRENERGIC NERVOUS ACTIVITY USING I-123-METAIODOBENZYLGUANIDINE (MIBG) IN CARDIOMYOPATHY
- Preoperative dynamic lymphoscintigraphy predicts sentinel lymph node metastasis in patients with early breast cancer
- Effect of minodronic acid hydrate on hip geometry in Japanese women with postmenopausal osteoporosis.
- Changes in distribution of bone densitometry equipment from 1996 to 2006 in Japan
- Superoxide Generation by Nox1 in Guinea Pig Gastric Mucosal Cells Involves a Component with p67^-Ability(Biochemistry/Molecular Biology)
- Therapeutic effects of alendronate 35mg once weekly and 5mg once daily in Japanese patients with osteoporosis : a double-blind, randomized study
- Synovial sarcoma with extended occult period treated as juvenile rheumatoid arthritis : a case report
- Soft tissue sarcoma mimicking chronic hematoma : value of magnetic resonance imaging in differential diagnosis
- Bone mineral measurement in Japan
- Intra-abdominal metastases in musculoskeletal sarcomas
- Clear cell chondrosarcomas arising from rare sites
- Geranylgeranylacetone stimulates mucin synthesis in cultured guinea pig gastric pit cells by inducing a neuronal nitric oxide synthase
- Glutathione depletion inhibits oxidant-induced activation of nuclear factor-kappa B, AP-1, and c-Jun/ATF-2 in cultured guinea-pig gastric epithelial cells
- The Effect of Resistance Training on Body Composition and Resting Metabolic Rate in Young Women (Kawasaki Medical Welfare Journal Vol.8,No.2,1998 Abstracts)
- Interleukin 10 inhibits interferon γ- and tumor necrosis factor α-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon
- Dietary α-Linked Galacto-Oligosaccharide Suppresses Ovalbumin-Induced Allergic Peritonitis in BALB/c Mice
- Reverse Reaction of Aspergillus niger APC-9319 α-Galactosidase in a Supersaturated Substrate Solution : Production of α-Linked Galactooligosaccharide (α-GOS)
- Cell Engineering and Molecular Gastric Physiology
- Effect of Renal Artery Ligation on Serum Lipids in Rats
- A Comparison of the Growth Rate of Rats on a Pellet Diet and a Semi Synthetic Diet
- The Effect of Aging on the Serum Biochemistry of Rats with a 50 % Distal Small Bowel Resection
- Changes due to Aging in the Serum Biochemical Profile and Weights of Internal Organs Using the Rat as a Model
- A Collection Method and Its Application to Biliopancreatic Exocretional Experiments on Conscious Rats
- Current status of hip bone densitometry in Japan : a nationwide survey
- A Comparison of Scintigraphy with Tumor-seeking Radiopharmaceuticals to Detect an Experimental Bone Tumors in the Rabbits
- Changes in Sex Hormones and Calcium Regulating Hormones with Reference to Bone Mass Associated with Aging
- Radioimmunoassay for Human Calcitonin Employing Synthetic Calcitonin M: Ist clinical Application
- Long-term Effects of a 30% Hepatectomy on Serum Biochemistry and Longevity in Male Adult Rats
- Spontaneous Bilateral Intracerebral Hemorrhage Occurring Simultaneously : Case Report
- Roles of Circulating Carcinoembryonic Antigen and Calcitonin in Diagnosis of Medullary Thyroid Carcinoma: A Comparative Study
- Incidence of Herpes Zoster in Pediatricians and Family Practitioners : Estimation of Efficacy of Varicella Vaccine for Protection Against Herpes Zoster in the Elderly
- Kinetics of gastric epithelial cells in duodenal ulcer: Local environmental factors controlling the proliferation and differentiation of gastric epithelial cells
- Design of a pragmatic approach to evaluate the effectiveness of concurrent treatment for the prevention of osteoporotic fractures
- Implications of heat shock / stress proteins for medicine and disease
- Usual Dietary Intake of Fermented Soybeans (Natto) Is Associated with Bone Mineral Density in Premenopausal Women
- Immunological background in children with persistent diarrhea in Ghana
- Recommended Daily Exercise for Japanese Does Not Increase the Protein Requirement in Sedentary Young Men
- Japanese Dietary Protein Allowance is Sufficient for Moderate Physical Exercise in Young Men
- Alteration of the Respiratory Burst and Phagocytosis of Macrophages under Protein Malnutrition
- Role of miR-19b and its target mRNAs in 5-fluorouracil resistance in colon cancer cells
- Amino Acids and Glucose Differentially Increased Extracellular 5-Hydroxyindoleacetic Acid in the Rat Brain.
- Measurement of regional cerebral blood flow with ^I-IMP using one-point venous blood sampling and causality analysis : Evaluation by comparison with conventional continuous arterial blood sampling
- Three years of treatment with minodronate in patients with postmenopausal osteoporosis
- Guidelines for the use of bone metabolic markers in the diagnosis and treatment of osteoporosis (2012 edition)
- Diagnostic criteria for primary osteoporosis : year 2012 revision