Usual Dietary Intake of Fermented Soybeans (Natto) Is Associated with Bone Mineral Density in Premenopausal Women
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概要
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Fermented soybeans (Natto), a traditional Japanese food, contain more than 100 times as much vitamin K2 as various cheeses and are considered to promote γ-carboxylation. Thus it is conceivable that Natto may play a preventive role in the development of osteoporosis. In this study, the relationships between the bone stiffness index measured by ultrasound, bone turnover markers, and lifestyle factors, including Natto intake, were examined in relation to vitamin D receptor (VDR) polymorphism. Among 117 premenopausal volunteers, approximately 75% were bb homozygotes, 20% were Bb heterozygotes, and only5% were BB homozygotes. The B allele group and the bb group were subdivided according to Natto intake. In a monovariate analysis, no significant differences in indices for dietary intake, including Ca and vitamin D intake, were observed. The stiffness index in the B allelegroup, however, was slightly lower than in the bb groups when there was no Natto intake. There were no significant differences in serum ALP and Gla-osteocalcin, bone formationmarkers, or NTx and Ca in urine, bone resorption markers. A logistic regression test, including the interactional effect of Natto intake and VDR RFLP, indicated that the B allele group was a risk factor of bone mineral loss and that Natto was effective in maintaining bone stiffness in this group. Although the present study was cross sectional and requires longitudinal investigation, Natto may improve the bone health of people who have a low affinity receptor for vitamin D.
- 財団法人 学会誌刊行センターの論文
- 2002-06-01
著者
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Fukunaga Masao
長崎大学 医学部放射線科
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Fukunaga Masao
Department Of Nuclear Medicine Kawasaki Medical School
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Fukunaga Masao
徳島大学 大学院ヘルスバイオサイエンス研究部運動機能外科学
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Fukunaga Masao
Kawasaki Medical School Okayama Jpn
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Katsuyama Hironobu
金沢大学 医学部環境生体分子応答学
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Saijoh K
Kanazawa Univ. School Of Medicine Kanazawa Jpn
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Saijoh Kiyofumi
金沢大学 医学系研究科衛生学
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Saijoh Kiyofumi
金沢大学 衛生
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Saijoh Kiyofumi
Department Of Environmental And Molecular Bio-informatics Kanazawa University School Of Medicine
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IDEGUCHI Seiji
Departments of Health Care Medicine, Kawasaki Medical School
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Katsuyama Hironobu
Department Of Public Health Kawasaki Medical College
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Sunami Shigeo
Departments Of Public Health Kawasaki Medical School
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Ideguchi Seiji
Departments Of Health Care Medicine Kawasaki Medical School
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Fukunaga Masao
Department Of Geriatric Medicine Graduate School Of Medicine The University Of Tokyo
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Sumino Kimiaki
Osaka Occupational Health Service Center Japan Industrial Safety And Health Association
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Katsuyama Hironobu
Dep. Of Public Health Kawasaki Medical Univ.
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IDEGUCHI Seiji
Departments of Health Care Medicine
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SUNAMI Shigeo
Departments of Public Health
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