Radioimmunoassay for Human Calcitonin Employing Synthetic Calcitonin M: Ist clinical Application
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概要
- 論文の詳細を見る
A sensitive and reliable radioimmunoassay for human calcitonin was described and applied to preliminary clinical studies.<SUP>125</SUP>I-labelled synthetic human calcitonin M was purified by gel filtration with Sephadex G-25 and G-100. A nonequilibrium incubation system was applied at the final volume of incubation mixture of 500μ<I>l</I>, in which pooled plasma from normal subjects or hormone free serum was used as carrier protein at 20% incubation mixture. Dextran T 40 coated charcoal, resuspended in 1% bovine serum albumin buffer, was used for the separation of free from bound tracer. This showed the least nonspecific adsorption of tracer to charcoal. The assay was sensitive to 0.1ng per milliliter of plasma. Recovery of synthetic human calcitonin added to plasma was found to be 101%(S.D., ±8). Diluted plasma from a patient with medullary thyroid carcinoma showed a dilution curve parallel to standards. Basal calcitonin levels were less than 0.3ng/ml in normal subjects. Relatively high values were found in patients with chronic renal failure and in patients with malignant tumors. Extremely elevated values were found in patients with medullary thyroid carcinoma. Provocative calcium infusion tests were also performed.
- 社団法人 日本内分泌学会の論文
著者
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TORIZUKA KANJI
Department of Nuclear, Medicine Kyoto University School of Medicine
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MORITA Rikushi
Shiga University of Medical Science
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Morita Rikushi
Department Of Neurosurgery Kinki University Medical School
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Yamamoto Itsuo
Department Of Radiology Shiga University Of Medical Science
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MORI TORU
Department of Laboratory Medicine, Kyoto University Graduate School of Medicine
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Fukunaga Masao
Department Of Geriatric Medicine Graduate School Of Medicine The University Of Tokyo
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Mori Toru
Department Of Internal Medicine Division Of Dermatology Faculty Of Medicine Saga University
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Mori Toru
Department Of Environment Conservation Faculty Of Agriculture Ehime University
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Torizuka Kanji
Department Of Nuclear Faculty Of Medicine Kyoto University
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MORITA RIKUSHI
Department of Radiology, Kyoto University, Shogoin Kawaramachi
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YAMAMOTO ITSUO
Department of Radiology, Kyoto University, Shogoin Kawaramachi
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YAMAMOTO ITSUO
Department of Nuclear Medicine and Radiology, Kyoto University School of Medicine
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FUKUNAGA MASAO
Department of Radiology, Kyoto University, Shogoin Kawaramachi
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TORIZUKA KANJI
Department of Radiology, Kyoto University, Shogoin Kawaramachi
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