Detection of TSH-Binding Inhibitor Immunoglobulins by Using the Triton-Solubilized Receptor from Human Thyroid Membranes
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概要
- 論文の詳細を見る
A radioreceptor assay of TSH using Triton-solubilized human thyroid receptors was applied to the detection of TSH-binding inhibitor immunoglobulins (TBII). In 26 untreated patients with Gravesdisease, 20 (76.9%) were found positive in this assay, while 18 (69.2%) cases were found positive by the conventional assay using human thyroid particulate receptors. In 25 patients with goitrous Hashimotos thyroiditis, 2 (8.0%) were found positive by the assay using soluble receptor, while 3 (12.0%) were found positive by the conventional one. A significant correlation was found between TBII activities in the patients with untreated Graves disease detected by these two assay systems (r=0.69; n=26; p<0.001). These data support the concept that TBII are antibodies against the TSH receptor or its closely related structures.
- 社団法人 日本内分泌学会の論文
著者
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飯田 泰啓
京都大学医学部核医学科教室
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TORIZUKA KANJI
Department of Nuclear, Medicine Kyoto University School of Medicine
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Kasagi Kanji
Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University Graduate School Of Medicine
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Iida Y
Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University Graduate School Of Medicine
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Iida Yasuhiro
Department Of Applied Chemistry Faculty Of Engineering Kanagawa Institute Of Technology
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Konishi Junji
Department Of Nuclear Medicine And Diagnostic Imaging Graduate School Of Medicine Kyoto University
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Iida Yasuhiko
Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University Graduate School Of Medicine
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KUMA Kanji
Kuma Hospital
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Torizuka Kanji
Department Of Nuclear Faculty Of Medicine Kyoto University
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TORIZUKA KANJI
Department of Nuclear Medicine, Kyoto University School of Medicine
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