腸管からのカルシウム吸収及び血清1,25-dihydroxyvitaminDレベルに及ぼす, 1,25-dihydroxyvitaminD3及び1α-hydroxyvitaminD3経口投与の効果健常人及び閉経後骨粗懸症患者での検討

概要

論文の詳細を見る
The effects of short term administration (12 days) of oral doses of 1, 25-dihydroxyvitamin D3 (1, 25-(OH)2D3 : 0.5μg/day) and 1α-hydroxyvitamin D3 (1α-(OH)D3 : 1.0μg/ day) on intestinal calcium absorption and serum 1, 25-(OH)2D levels were studied in 5 normal and 2 postmenopausal osteoporotic subjects. Fractional intestinal calcium absorption (mean ± SD) assessed by a whole body counting method was unchanged when measured on two separate occasions (0.242 ± 0.026 to 0.223 ± 0.022) in 5 normal male subjects ranging in age from 28 to 48 (mean = 35.4). A similar increase was observed in intestinal calcium absorption in the normal subjects when they were treated either with 1, 25-(OH)2D3 or 1α-(OH)D3 (0.091 ± 0.047 : p<0.02, 0.124 ± 0.055 : p<0.01, respectively). Serum 1, 25 (OH)2D level showed no significant change in basal state in the normal subjects (26.1 ± 13.6 to 22.4 ± 8.1pg/ml), but elevated above the basal range after administration of the two vitamin D metabolites (p<0.01, both) : the increment was significantly larger (p<0.01) after treatment with 1α-(OH)D3 (70.6 ± 20.4pg/ml) than with 1, 25-(OH)2D3 (32.1 ± 10.9pg/ml). In addition, there was a positive correlation between intestinal calcium absorption and serum 1, 25-(OH)2D levels in the normal subjects in their basal state (r=0.76, p<0.02). In two osteoporotic subjects, the increment of calcium absorption after 1α-(OH)D3 treatment was 0.180 ± 0.014 and that of serum 1, 25-(OH)2D, 58.0pg/ml (n=1). The data suggest that in normal subjects, 1α-(OH)D3 is about half as potent as 1, 25-(OH)2D3 when administered at oral doses of 1.0μg/day or less in stimulating intestinal calcium transport. Although the two vitamin D metabolites exert their effects on the intestine and are quantitatively equivalent at these doses, there is a discordance between the changes in serum 1, 25-(OH)2D level after treatment with the two vitamin D derivatives : this might be attributed to possible direct binding of orally administered 1, 25-(OH)2D3 to its intestinal receptors and to more rapid metabolic removal of 1, 25-(OH)2D3 from the circulation.
日本内分泌学会の論文

腸管からのカルシウム吸収及び血清1,25-dihydroxyvitaminDレベルに及ぼす, 1,25-dihydroxyvitaminD<SUB>3</SUB>及び1α-hydroxyvitaminD<SUB>3</SUB>経口投与の効果健常人及び閉経後骨粗懸症患者での検討

スポンサーリンク

概要

著者

関連論文

スポンサーリンク

腸管からのカルシウム吸収及び血清1,25-dihydroxyvitaminDレベルに及ぼす, 1,25-dihydroxyvitaminD<SUB>3</SUB>及び1α-hydroxyvitaminD<SUB>3</SUB>経口投与の効果 健常人及び閉経後骨粗懸症患者での検討

スポンサーリンク

概要

著者

関連論文

スポンサーリンク

腸管からのカルシウム吸収及び血清1,25-dihydroxyvitaminDレベルに及ぼす, 1,25-dihydroxyvitaminD<SUB>3</SUB>及び1α-hydroxyvitaminD<SUB>3</SUB>経口投与の効果健常人及び閉経後骨粗懸症患者での検討