Adipocyte-TSH-receptor-related antibodies in Graves' disease detected by immunoprecipitation.
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概要
- 論文の詳細を見る
Fat cell TSH receptor-related antibodies were detected by immunoprecipitation of <SUP>125</SUP>I-TSH-receptor complexes and the nature of the antibodies was analyzed. To <SUP>125</SUP>I-TSH prebound to Triton-solubilized receptors from guinea pig fat tissues, 50μg of immunoglobulin G (IgG) was added and precipitation was effected by the addition of antihuman IgG.<BR>Immunoprecipitation values in 13 patients with Graves' disease were significantly (p<0.05) higher than those in 11 normal subjects. No significant increase in the values was seen in 8 patients with Hashimoto's disease. No correlation was observed between immunoprecipitation values and titers of antimicrosomal and antithyroglobulin antibodies. Neither was there any correlation between the values and TSH-binding inhibitor immunoglobulins (TBII) detected by the radioreceptor assay. The IgG fractions positive for the immunoprecipitation antibody were found to be poor human thyroid stimulators (HTS) relative to their TBII activities. And a highly significant correlation was observed between TBII and HTS activities among IgGs without detectable antibody by immunoprecipitation (r=0.907; p<0.005; n=7). These findings 1) demonstrate that immunoprecipitation assay using fat cell TSH receptor may detect TSH receptor-related antibodies different from TBII in patients with Graves' disease and 2) suggest the antibodies may recognize determinants on the receptor or its vicinity that do not participate in the binding of TSH or thyroid stimulating antibody, and may interfere with thyroidal response to these stimulators.
- 社団法人 日本内分泌学会の論文
著者
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Kasagi Kanji
Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University Graduate School Of Medicine
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Iida Yasuhiro
Department Of Applied Chemistry Faculty Of Engineering Kanagawa Institute Of Technology
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Konishi Junji
Department Of Nuclear Medicine And Diagnostic Imaging Graduate School Of Medicine Kyoto University
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IKEKUBO Katsuji
Department of Endocrinology, Kobe City General Hospital
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Kuma Kanji
Department Of Surgery Kuma Hospital
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Torizuka Kanji
Department Of Nuclear Faculty Of Medicine Kyoto University
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KONISHI JUNJI
Department of Nuclear Medicine, Kyoto University School of Medicine
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IKEKUBO KATSUJI
Department of Nuclear Medicine, Kyoto University School of Medicine
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IIDA YASUHIRO
Department of Nuclear Medicine, Kyoto University School of Medicine
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KASAGI KANJI
Department of Nuclear Medicine, Kyoto University School of Medicine
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KUMA KANJI
Department of Nuclear Medicine, Kyoto University School of Medicine
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TORIZUKA KANJI
Department of Nuclear Medicine, Kyoto University School of Medicine
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- Introduction
- Adipocyte-TSH-receptor-related antibodies in Graves' disease detected by immunoprecipitation.