Roles of Circulating Carcinoembryonic Antigen and Calcitonin in Diagnosis of Medullary Thyroid Carcinoma: A Comparative Study
スポンサーリンク
概要
- 論文の詳細を見る
Carcinoembryonic antigen (CEA) and calcitonin (CT) were simultaneously determined in sera and tumor tissues from 15 patients with medullary carcinoma of the thyroid (MCT). Serum CEA was increased in all but one patient, and CT did in all of them. Both levels were significantly related to the weight of excised tumor, but not to the presence of metastasis. Furthermore, a significant correlation was noted between the basal levels of CT and CEA. Both levels fell to normal after a radical operation had been performed. Tissue concentrations of CEA and CT in the MCT were more than 100 times those in hyperthyroidism, and the ratios of tissue over serum levels averaged 770 in CEA and 1000 in CT. In the calcium infusion test, CEA levels were not significantly changed in contrast with a distinct increase in CT levels. The results indicate that CEA and CT represent separate activities of the tumor cells, and that circulating CEA together with CT is a useful indicator in the diagnosis and follow-up of the disease.
- 社団法人 日本内分泌学会の論文
著者
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TORIZUKA KANJI
Department of Nuclear, Medicine Kyoto University School of Medicine
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Ishikawa Nobuyoshi
Department of Internal Medicine University of Tsukuba
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Morita Rikushi
Department Of Neurosurgery Kinki University Medical School
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Fukunaga Masao
Department Of Geriatric Medicine Graduate School Of Medicine The University Of Tokyo
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HAMADA SATOSHI
Radioisotope Research Center, Kyoto University
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YOSHII MASAO
Departments of Radiology, Kyoto University, School of Medicine
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FUKASE MASAICHI
Internal Medicine II, Kyoto University, School of Medicine
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Torizuka Kanji
Department Of Nuclear Faculty Of Medicine Kyoto University
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MORITA RIKUSHI
Departments of Radiology, Kyoto University, School of Medicine
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FUKUNAGA MASAO
Departments of Radiology, Kyoto University, School of Medicine
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ISHIKAWA NOBUYOSHI
Departments of Radiology, Kyoto University, School of Medicine
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TORIZUKA KANJI
Departments of Radiology, Kyoto University, School of Medicine
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