Technetium-99m Methoxyisobutyl Isonitrile Scintigraphy of Bone Metastasis in Three Patients with Differentiated Thyroid Cancer

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We studied the usefulness of ^<99m>Tc-methoxyisobutyl isonitrile (MIBI) scintigraphy in the detection of bone metastases and in evaluation of therapeutical response to ^<131>I-Na in three patients with differentiated thyroid cancer. On ^<99m>Tc-MIBI scintigraphy, increased accumulations were observed in all bone metastatic lesions (14 lesions), whereas on bone scintigraphy using ^<99m>Tc-hydroxymethylene diphosphonate (^<99m>Tc-HMDP) both increased (eight lesions, 57%) and decreased (six lesions, 43%) accumulations were observed. Within two months after ^<131>I-Na treatment, all 14 lesions were unchanged on bone scintigraphy. However, on ^<99m>Tc-MIJBI scintigraphy, disappearance of uptake (six lesions, 43%) and decreased uptake (seven lesions, 50%) were observed in 13/14 lesions (93%). Therefore, ^<99m>Tc-MIBI scintigraphy was useful not only in the detection of bone metastatic lesions but also in evaluation of the therapeutical response to ^<131>I-Na in differentiated thyroid cancer.
川崎医科大学の論文