In Vivo Antitumor Activity of Novel Water-Soluble Taxoids(Pharmacology)
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概要
- 論文の詳細を見る
The antitumor activity of newly developed taxoids possessing a sugar moiety (glucose, galactose or mannose) to improve water solubility was evaluated. Galactose-bound taxoid (10-α-GAG-DT) proved superior to all other taxoids in both water solubility and antitumor activity. Therapeutic efficacy of 10-α-GAG-DT in terms of in vivo antitumor activity was found to be approximately equivalent to that of docetaxel, which is known to be superior to that of paclitaxel. The observation that the sugar moiety was gradually hydrolyzed in serum to release docetaxel indicates that 10-α-GAG-DT acts as a prodrug.
- 公益社団法人日本薬学会の論文
- 2008-06-01
著者
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HARA Kozo
Bio Research Corporation of Yokohama
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Hara Koji
Bio Research Corporation Of Yokohama
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Amano Tetsuya
Kaken Pharmaceutical Co. Ltd.
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MIKUNI Katsuhiko
Bio Research Corporation of Yokohama
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HARA Kozo
Ensuiko Sugar Refining Co., Ltd.
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MIKUNI KATSUHIKO
Ensuiko Sugar Refining Co., Ltd.,
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OKUMOTO Hiroshi
Department of Chemistry and Bioscience, Kurashiki University of Science and the Arts
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NAKANISHI Katsuyoshi
Ensuiko Sugar Refining Co., Ltd.
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HARA Koji
Ensuiko Sugar Refining Co., Ltd.
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IWATANI Wakao
Kaken Pharmaceutical Co., Ltd.
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NAKAMURA Kosho
Kaken Pharmaceutical Co., Ltd.
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TSUCHIYA Yoshinori
Kaken Pharmaceutical Co., Ltd.
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MANDAI Tadakatsu
Department of Life Science, Kurashiki University of Science & the Arts
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Iwatani Wakao
Kaken Pharmaceutical Co. Ltd.
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Nakamura Kosho
Kaken Pharmaceutical Co. Ltd.
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Mandai Tadakatsu
Department Of Life Science Kurashiki University Of Science & The Arts
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Mikuni K
Bio Research Corporation Of Yokohama
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Mikuni K
Carbohydrate Research Laboratory Ensuiko Sugar Refining Co. Ltd.
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Mikuni Katsuhiko
Ensuiko Sugar Refining Co. Ltd.
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Okumoto Hiroshi
Department Of Life Science Kurashiki University Of Science & The Arts
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Nakanishi Katsuyoshi
Ensuiko Sugar Refining Co. Ltd.
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Tsuchiya Yoshinori
Kaken Pharmaceutical Co. Ltd.
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OKUMOTO Hiroshi
Department of Chemical Technology, College of Science and Industrial Technology, Kurashiki University of Science and Arts
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Mandai Tadakatsu
Department of Chemical Engineering, Tokyo Institute of Technology
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