Enhancement of Water-Solubility and Bioactivity of Paclitaxel Using Modified Cyclodextrins(METHODS)
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概要
- 論文の詳細を見る
We investigated the aqueous solubility of paclitaxel using 11 kinds of cyclodextrins (CDs) and the bioactivity of the paclitaxel-CD inclusion complex. 2,6-Dimethyl β-cyclodextrin was the most effective and its solubility was 2.3mM in a 0.1M 2,6-dimethyl β-cyclodextrin aqueous solution. The inclusion complex of paclitaxel and 2,6-dimethyl β-cyclodextrin had a 1.23-fold polymerization activity as paclitaxel in a tubulin assay.
- 社団法人日本生物工学会の論文
- 2006-10-25
著者
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中島 伸佳
Graduate School Of Health And Welfare Okayama Prefectural University
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中島 伸佳
岡山県立大学短期大学部
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中島 伸佳
岡山県立短大
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ISHIHARA Kohji
Department of Chemistry, Kyoto University of Education
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HAMADA Hiroki
Department of Applied Science, Okayama University of Science
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Hamada H
National Institute Of Fitness And Sports In Kanoya
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NAKAJIMA Nobuyoshi
Industry, Government, and Academic Promotional Center, Regional Cooperative Research Organization, O
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Ishihara K
Dep. Of Life Sci. Okayama Univ. Of Sci. 1-1 Ridai-cho Kita-ku Okayama 700-0005 Jpn
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MIKUNI Katsuhiko
Bio Research Corporation of Yokohama
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MIKUNI Katsuhiko
Carbohydrate Research Laboratories, Ensuiko Sugar Refining Co., Ltd.
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Nakajima Nobuyoshi
Graduate School Of Health And Welfare Okayama Prefectural University
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Nakajima Nobuyoshi
Department Of Nutritional Science Faculty Of Health And Welfare Okayama Prefectural University
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Masuoka Noriyoshi
Department of Life Science, Okayama University of Science
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Hamada Hiroki
Materials And Devices Development Center Bu Sanyo Electric Co. Ltd.
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Masuoka Noriyoshi
Department Of Life Science Okayama University Of Science
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Masuoka Noriyoshi
Department Of Biochemistry Okayama University Graduate School Of Medicine And Dentistry
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Nakajima Noriyuki
Biotechno-logy Research Center Toyama Prefectural University
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Mikuni K
Bio Research Corporation Of Yokohama
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Mikuni K
Carbohydrate Research Laboratory Ensuiko Sugar Refining Co. Ltd.
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Mikuni Katsuhiko
Carbohydrate Research Laboratories Ensuiko Sugar Refining Co. Ltd.
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Hamada Hiroki
Department Of Applied Sci. Okayama University Of Science
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Nakajima Nobuyoshi
Industry Government And Academic Promotional Center Regional Cooperative Research Organization Okaya
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HAMADA Hiroki
Department of Applied Sci. , Okayama University of Science
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