Stereoselective Reduction of Carbonyl Compounds Using the Cell-Free Extract of the Earthworm, Lumbricus rubellus, as a Novel Source of Biocatalyst
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概要
- 論文の詳細を見る
We found the reducing activity toward carbonyl compounds in the cell-free extract of the earthworm, Lumbricus rubellus. The earthworm extract had a reducing activity for keto esters in the presence of NADH or NADPH as a coenzyme. The earthworm extract reduced ethyl 3-methyl-2-oxobutanoate to the corresponding alcohol with a high enantiomeric excess (91%, R-form) at 50 °C in the presence of NADH. In particular, ethyl 2-oxoheptanoate was exclusively reduced to the corresponding (R)-hydroxyl ester with a high enantiomeric excess (>99%).
- 社団法人 日本農芸化学会の論文
- 2006-12-23
著者
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ISHIHARA Kohji
Department of Chemistry, Kyoto University of Education
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NAKAJIMA Nobuyoshi
Industry, Government, and Academic Promotional Center, Regional Cooperative Research Organization, O
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Ishihara Kohji
Department Of Life Science Okayama University Of Science
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Nakajima Nobuyoshi
Ind. Government And Academic Promotional Center Regional Cooperative Res. Organization Okayama Prefe
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Nakajima Nobuyoshi
Industry Government And Academic Promotional Center Regional Cooperative Research Organization Okaya
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