Effects of Adenine-Nucleotides on the Sequence-Specificity of Origin Recognition Complex-Binding to DNA
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概要
- 論文の詳細を見る
We examined effects of adenine-nucleotides on the sequence-specificity of origin recognition complex (ORC)-binding to DNA, using a gel electrophoretic mobility shift assay. The sequence-specific DNA binding of ORC was observed in the presence of ATP or ATP-γ-S but not in the presence of adenosine 5'-diphosphate (ADP) or in the absence of any adenine-nucleotides. In contrast, the sequence-independent DNA binding of ORC was observed under any one of these conditions. These results suggest that ATP increases the sequence-specificity of ORC-binding to DNA. In relation to the requirement for incubation at high temperature and inhibition by cardiolipin, there was no significant difference between the sequence-specific and the sequence-independent DNA binding activities of ORC.
- 公益社団法人日本薬学会の論文
- 2002-05-01
著者
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土屋 照雄
Gifu Prefectural Hospital
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Tsuchiya Tomofusa
岡山大学 薬学部
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Tsuchiya Tomofusa
Faculty Of Pharmaceutical Sciences Okayama University
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Mizushima Tohru
Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
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Mima Takehiko
岡山大学 医歯薬学総合研究科
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Miki T
Faculty Of Pharmaceutical Sciences Kyushu University
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Tsuchiya T
Faculty Of Pharmaceutical Sciences Okayama University
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Tsuchiya T
Okayama Univ. Okayama
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MIZUSHIMA Tohru
Faculty of Pharmaceutical Sciences, Okayama University
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Lee Jong-ryul
Faculty Of Pharmaceutical Sciences Okayama University
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Yamaguchi Y
The Kitasato Institute
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Takahashi N
Faculty Of Pharmaceutical Sciences Okayama University
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YAMAGUCHI Yoshihiro
Faculty of Science and Technology, Kinki University
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Yamaguchi Yoshihiro
Faculty Of Science And Technology Kinki University
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Takahashi Naoko
Faculty Of Pharmaceutical Sciences Okayama University
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Yamaguchi Y
Environmental Safety Center Kumamoto University
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Takenaka Hitomi
Faculty of Pharmaceutical Sciences, Okayama University
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Makise Masaki
Faculty of Pharmaceutical Sciences, Okayama University
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Makise Masaki
Graduate School Of Medical And Pharmaceutical Sciences Kumamoto University
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Tsuchiya T
Faculty Of Pharmaceutical Sciences Hokuriku University
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Takenaka Hitomi
Faculty Of Pharmaceutical Sciences Okayama University
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Mizushima Tohru
Department Of Molecular Microbiology Graduate School Of Medicine Dentistry And Pharmaceutical Scienc
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Mizushima Tohru
Faculty Of Pharmaceutial Sciences Kyushu University
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Mizushima Tohru
Faculty Of Engineering. Tokai University
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Tsuchiya Tomofusa
Department Of Microbiology Fujita Health University
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Mizushima T
Faculty Of Pharmaceutial Sciences Kyushu University
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Yamaguchi Yoshihiro
Faculte Des Science Universite Libre De Bruxelles
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Makise Masaki
Faculti of Pharmaceutical Sciences Okairama University
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Mizushima Tohru
Faculti of Pharmaceutical Sciences Okairama University
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