Psychotropic Drugs and Local Anesthetics Restore Cardiolipin-Inhibited Mammalian DNA Topoisomerase I Activity
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概要
- 論文の詳細を見る
The activity of mammalian topoisomerase I is inhibited by acidic phospholipids. We investigated the effect of psychotropic drugs and local anesthetics on cardiolipin-inhibited calf thymus DNA topoisomerase I activity. Chlorpromazine, promethazine, and imipramine, which interact with phospholipids, suppressed the inhibitory effect of cardiolipin. The present results suggest that relaxation of DNA supercoiling is involved in the cytotoxic action of these drugs.
- 公益社団法人日本薬学会の論文
- 1997-12-15
著者
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MIZUSHIMA Tohru
Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University
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Mizushima Tohru
Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University
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Miki T
Faculty Of Pharmaceutical Sciences Kyushu University
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UENO Akiko
Department of Medicine III, Okayama University Medical school
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OHTSUKA Yoshihisa
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kyushu University
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SEKIMIZU Kazuhisa
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kyushu University
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Ohtsuka Yuko
General Laboratory Bml Inc.
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Ueno Akiko
Department Of Microbiology Faculty Of Pharmaceutical Sciences Kyushu University
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Ueno Akiko
Department Of Environmental And Radiological Health Sciences Colorado State University:national Inst
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Mizushima Tohru
Faculty Of Pharmaceutial Sciences Kyushu University
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Sekimizu K
Univ. Tokyo Tokyo
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SHAH Gulzar
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kyushu University
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KATAOKA Kazuhiro
Department of Microbiology, Faculty of Pharmaceutical Sciences, Kyushu University
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Shah Gulzar
Department Of Microbiology Faculty Of Pharmaceutical Sciences Kyushu University
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Kataoka Kazuhiro
Department Of Microbiology Faculty Of Pharmaceutical Sciences Kyushu University
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Mizushima T
Faculty Of Pharmaceutial Sciences Kyushu University
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Ohtsuka Y
Department Of Microbiology Faculty Of Pharmaceutical Sciences Kyushu University
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