A Versatile Route to 3-Benzoheteroepines Containing Group 15 and 16 Heavier Elements Involving Several Novel Ring Systems, and Their Thermal Stabilities
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概要
- 論文の詳細を見る
The C-unsubstituted 3-benzoheteroepines (2a-g) containing group 15 (P, As, Sb, and Bi) and group 16 (S, Se, and Te) heavier elements were prepared by the reaction of the corresponding metal reagents with (Z,Z)-o-bis(β-lithiovinyl)benzene (5) which was derived in two steps from a common o-phthalaldehyde (3). The heteroepines (2) thus obtained were thermally labile towards heteroatom extrusion, and their half-lives on heating estimated from ^1H-NMR spectral analysis showed that the 3-benzoheteroepines (2) were far less stable than the corresponding 1-benzoheteroepines (1). The 2,4-bis(trimethylsilyl)-3-benzoheteroepines (17) containing Sb, Bi, and Te were also prepared from o-diiodobenzene (9) in 6 steps and were found to be more stable than the corresponding C-unsubstituted heteroepines (2).
- 公益社団法人日本薬学会の論文
- 2003-11-01
著者
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土屋 照雄
Gifu Prefectural Hospital
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Tsuchiya Tomofusa
岡山大学 薬学部
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KURITA Jyoji
Faculty of Pharmaceutical Sciences, Hokuriku University
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Tsuchiya T
Faculty Of Pharmaceutical Sciences Okayama University
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Tsuchiya T
Okayama Univ. Okayama
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TSUCHIYA Takashi
Faculty of Pharmaceutical Sciences, Josai University
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YASUIKE Shuji
Faculty of Pharmaceutical Sciences, Hokuriku University
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Kurita J
Faculty Of Pharmaceutical Sciences Hokuriku University
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Kurita Jyoji
Faculty Of Pharmaceutical Sciences Hokuriku University
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Yasuike S
Faculty Of Pharmaceutical Sciences Hokuriku University
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Tsuchiya T
Faculty Of Pharmaceutical Sciences Hokuriku University
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KIHARADA Tsutomu
Faculty of Pharmaceutical Sciences, Hokuriku University
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Tsuchiya Tomofusa
Department Of Microbiology Fujita Health University
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Yasuike Shuji
Faculty Of Pharmaceutical Sciences Hokuriku University
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Kiharada Tsutomu
Faculty Of Pharmaceutical Sciences Hokuriku University
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Tsuchiya Takashi
Faculty Of Pharmaceutical Sciences Hokuriku University
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