Carbonylative Cross-Coupling Reaction of Ethynylstibane with Aryl Iodides

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概要

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• Palladium-catalyzed carbonylative cross-coupling reaction of ethynylstibane (Ph〓SbPh_2) and aryl iodides (Ar-I) is described. The reaction of the stibanes and the halides under 1 atm of carbon monoxide in N,N-dimethylacetamide using a combination of 5 mol% Pd(OAc)_2 and 4 equivalents (20mol%) of PPh_3 brought about carbonylative cross-coupling reaction to afford arylethynylketones [ArC(O)〓Ph] in good yields along with a small amount of directly coupled products, aryl acetylens (Ar〓Ph). Formation of the side product was completely suppressed by conducting the reaction under high CO pressure (20 atm) conditions. The present method provides a variety of carbonylated products in good yield even with electron-deficient aryl iodides which usually give inferior results due to their tendency to undergo decarbonylation in the cross-coupling reaction of ethynylstibanes and acyl halides.

• 2006-05-01

著者

• KAKUSAWA Naoki

  Faculty of Pharmaceutical Sciences, Hokuriku University

• KURITA Jyoji

  Faculty of Pharmaceutical Sciences, Hokuriku University

• Kakusawa Naoki

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Kurita Jyoji

  Faculty Of Pharmaceutical Sciences Hokuriku University

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