Argadin, a New Chitinase Inhibitor, Produced by Clonostachys sp.FO-7314
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概要
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A new chitinase inhibitor, designated as argadin (1), was isolated form the cultured broth of a fungal strain FO-7314. The strain was identified as Clonostachys sp. from the morphological characteristics. Argadin was purified from the cultured mycelium by a combination of cation exchange, adsorption and gel filtration chromatographic methods. The structure of argadin was elucidated as cyclo(N^ω-acetyl-L-arginyl-D-prolyl-homoseryl-histidyl-L-2-aminoadipyl) in which homoseryl γ-methylene bonded to histidyl α-amino residue. The IC_<50> value of argadin against Lucilia cuprina (blowfly) chitinase was 150 nM at 37℃ and 3.4 nM at 20℃. Argadin arrested the moult of cockroach larvae upon injection into the ventral abdominal part.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
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Omura Satoshi
Research Center For Biological Function The Kitasato Institute And School Of Pharmaceutical Sciences
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MASUMA Rokuro
Research Center for Biological Function, The Kitasato Institute
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IWAI Yuzuru
Research Center for Biological Function, The Kitasato Institute
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SHIOMI Kazuro
Research Center for Biological Function, The Kitasato Institute, and School of Pharmaceutical Scienc
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ARAI Noriko
Research Center for Biological Function, The Kitasato Institute
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Masuma R
Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato Univ
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Yamaguchi Y
The Kitasato Institute
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Turberg Andreas
Bayer AG, Biological Technology Center, Business Group Animal Health
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Kolbl Heinz
Bayer AG, Biological Technology Center, Business Group Animal Health
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YAMAGUCHI Yuuichi
Research Center for Biological Function, The Kitasato Institute
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Kolbl Heinz
Bayer Ag Biological Technology Center Business Group Animal Health
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YAMAGUCHI Yuuici
Research Center for Biological Function, The Kitasato Institute
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Arai Noriko
The Kitasato Institute
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Suzuki Kunihiko
Research Center For Biological Function The Kitasato Institute And Pharmaceutical Sciences Kitasato
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岩井 雄二
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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MATSUI Ryosuke
School of Pharmaceutical Sciences Kitasato University
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Iwai Y
Kitasato Institute For Life Sciences Kitasato University
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Iwai Yuzuru
Research Center For Biological Function The Kitasato Institute
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Turberg Andreas
Business Group Animal Health Research And Development Bayer Healthcare Ag
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Turberg Andreas
Bayer Ag Biological Technology Center Business Group Animal Health
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Masuma R
Kitasato Institute For Life Sciences And Graduate School Of Infection Control Sciences Kitasato Univ
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Shiomi Kazuro
Research Center For Biological Function The Kitasato Institute And School Of Pharmaceutical Sciences
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Omura Satoshi
Research Center For Biological Function The Kitasato Institute
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