KF4939, a new anti-platelet agent, inhibits activation of phospholipase C and A2 in rabbit platelets.
スポンサーリンク
概要
- 論文の詳細を見る
Effect of KF4939 on activation of phospholipase C and A<SUB>2</SUB> was examined by using rabbit platelets prelabelled with [<SUP>14</SUP>C]-arachidonic acid. The results showed that KF4939 inhibited the activation of the two phospholipases, separately. The inhibition of phospholipase C activation is thought to be a possible mechanism of KF4939 to inhibit aggregation and secretion which are independent of the synthesis of cyclooxygenase products such as thromboxane A<SUB>2</SUB>.
- 公益社団法人 日本薬理学会の論文
著者
-
Kubo Kazuhiro
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
-
KUBO Kazuhiro
Pharmaceuticals Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
-
KUMADA Yoko
Pharmaceuticals Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
-
YAMADA Koji
Tokyo Research Laboratories Kyowa Hakko Kogyo Co., Ltd.
関連論文
- Effects of KF-14363 on Liver Fibrosis in Rats with Chronic Liver Injury Induced by Carbon Tetrachloride
- Effects of 1-[(2-Thiazolin-2-yl) amino] acetyl-4-(1,3-dithiol 2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione Hydrochloride (KF-14363) on Liver Regeneration and Function of Hepatic Mitochondria in Partially Hepatectomized Rats
- EFFECTS OF ECARAZINE, PRAZOSIN, PHENTOLAMINE AND HEXAMETHONIUM ON THE VASOPRESSOR REFLEXES INDUCED BY BILATERAL CAROTID ARTERY OCCLUSION AND HEAD-UP TILTING IN CATS
- PROTECTIVE EFFECT OF FLUNARIZINE AGAINST CEREBRAL HYPOXIA-ANOXIA IN MICE AND RATS
- Inhibitory Effect of KW-3049,A New 1,4-Dihydropyridine Calcium Antagonist, on the Reduction of Myocardial Creatine Kinase Activity and High-Energy Phosphate Content in Rats Subjected to Coronary Artery Ligation
- Effects of 1-((2-Thiazolin-2-yl)amino)acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione Hydrochloride (KF-14363) on Active Oxygen Production.
- Protection by benidipine hydrochloride (KW-3049), a calcium antagonist, of ischemic kidney in rats via inhibitions of Ca-overload, ATP-decline and lipid peroxidation.
- KF4939, a new anti-platelet agent, inhibits activation of phospholipase C and A2 in rabbit platelets.
- Hepatoprotective Effects of 1-((2-Thiazolin-2-yl)-amino)acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione Hydrochloride (KF-14363) in Various Experimental Liver Injuries.