Effects of 1-((2-Thiazolin-2-yl)amino)acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione Hydrochloride (KF-14363) on Active Oxygen Production.
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概要
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The effects of KF-14363 on active oxygen production and membrane stabilization were studied. KF-14363 did not affect hypotonic hemolysis (10% and 70%) and did not inhibit lipid peroxide production induced by t-butyl hydroperoxide at concentrations of less than 100 μM. KF-14363 significantly inhibited active oxygen production in peritoneal exudate cells (PEEL) stimulated with arachidonic acid, A23187 and carbon tetrachloride (CC14) at concentrations over 10 μM, 100 μM and 1 μM, respectively. It tended to inhibit formyl-methionyl-leucyl-phenylalanine-stimulated production of active oxygen in PEEC at concentrations over 10 μM, but there was no significant difference owing to large dispersion. Superoxide dismutase (SOD, 10<SUP>4</SUP> U/ml) significantly inhibited CCl<SUB>4</SUB>-stimulated production of active oxygen in PEEC. KF-14363 inhibited the radical production from CCl<SUB>4</SUB> in the presence of a 9000 ×<I>g</I> supernatant fraction of the rat liver which was administered with enzyme induction compounds (S9 mix). SOD (10<SUP>4</SUP> U/ml) was not effective in this system. In conclusion, KF-14363 inhibited active oxygen production in PEEC induced by various stimulants and also the radical formation from CCl<SUB>4</SUB> in the presence of S9 mix solution.
- 公益社団法人 日本薬理学会の論文
著者
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Kubo Kazuhiro
Pharmaceutical Research Laboratories Kyowa Hakko Kogyo Co. Ltd.
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Yoshitake Ikufumi
Pharmaceutical Research Laboratories Of Kyowa Hakko Kogyo Co. Ltd.
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Yoshitake Ikufumi
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd.
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