ANTAGONISM OF KW-5338 (DOMPERIDONE) AGAINST EMESIS AND DEPRESSION OF INTESTINAL MOTILITY INDUCED BY L-DOPA
スポンサーリンク
概要
- 論文の詳細を見る
KW-5338 (domperidone), a new dopamine antagonist, is considered to be an agent to cross the blood-brain barrier with difficulty. The antagonistic activities of KW-5338 against L-DOPA were investigated. KW-5338 showed a strong anti-emetic action against L-DOPA induced emesis in beagle dogs (ED_<50>=0.056 mg/kg (p. o.)) and restored the L-DOPA induced depression of intestinal motility to some extent, while it did not antagonize anti-tremorine activities of L-DOPA and trihexyphenidyl in mice. These results suggest that KW-5338 prevents side effects of L-DOPA such as nausea, vomiting and constipation, without reduction in therapeutic effects of L-DOPA in Parkinson's disease.
- 公益社団法人日本薬学会の論文
著者
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TANAKA MASAO
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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SHUTO KATSUICHI
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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Tanaka Masao
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Shuto Katsuichi
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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Kojima Tetsuo
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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SHIOZAKI SHIZUO
Pharmaceuticals Research Laboratory, Kyowa Hakko Kogyo Co., Ltd.
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Shiozaki Shizuo
Pharmaceuticals Research Laboratory Kyowa Hakko Kogyo Co. Ltd.
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SHIOZAKI Shizuo
Pharmaceutical Research Laboratories, Fuji Plant, Kyowa Hakko Kogyo Co., Ltd.
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KOJIMA Tetsuo
Pharmaceutical Research Laboratories, Fuji Plant, Kyowa Hakko Kogyo Co., Ltd.
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